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Results for "

C5 Protein (human)

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Inhibitory Antibodies

18

Recombinant Proteins

2

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128342
    Complement C5-IN-1
    1 Publications Verification

    		 Complement System Inflammation/Immunology
    Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
    Complement C5-IN-1
  • HY-P99365
    Ravulizumab

    ALXN1210

    		 Complement System Metabolic Disease
    Ravulizumab (ALXN1210) is a humanized monoclonal antibody that specifically binds with high affinity to the human complement protein C5. Ravulizumab can be used for the research of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis .
    Ravulizumab
  • HY-NP202C
    C5 Protein (human)

    		Complement System Inflammation/Immunology
    C5 Protein (human) is a naturally occurring glycosylated polypeptide containing two disulfide-linked chains. C5 is essential for the formation of the membrane attack complex (MAC) and is activated by all three pathways of complement activation .
    C5 Protein (human)
  • HY-P991067
    Vensobafusp alfa

    KP-104

    		 Complement System Inflammation/Immunology
    Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .
    Vensobafusp alfa

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