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Results for "

C 11

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Aldose Reductase (1) Amino Acid Derivatives (1) Apoptosis (2) Bacterial (5) Biochemical Assay Reagents (12) c-Myc (1) CD3 (1) Cytochrome P450 (4) Drug Isomer (2) E3 Ligase Ligand-Linker Conjugates (7) Endogenous Metabolite (3) Ferroptosis (1) Fluorescent Dye (1) HBV (1) IGF-1R (1) Influenza Virus (2) Isotope-Labeled Compounds (3) Ligands for E3 Ligase (2) Liposome (1) Microtubule/Tubulin (3) Mitochondrial Metabolism (1) Orphan Receptor (1) p38 MAPK (2) Peptide-Drug Conjugates (PDCs) (1) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (1) Reference Standards (1) Small Interfering RNA (siRNA) (7) STING (1) Trk Receptor (1)
By Research Areas:	Cancer (26) Endocrinology (2) Infection (5) Inflammation/Immunology (6) Metabolic Disease (7) Neurological Disease (1)
Click Chemistry:	Azide (2) Alkynes (1)
Oligonucleotides:	Cationic Lipids (1) Human Pre-designed siRNA Sets (7) siRNAs (7)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: 11β-HSD SHP2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1301

BODIPY 581/591 C11 Maximum Cited Publications 82 Publications Verification	Fluorescent Dye Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

HY-135869

*Mito-apocynin (C11)* 3 Publications Verification	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function .

HY-100861

*C-11*	ADC Payload Microtubule/Tubulin	Cancer
C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines .

HY-W800616

C11-PEG4-alcohol	Biochemical Assay Reagents	Others
C11-PEG4-alcohol is a linker with an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain increases the water solubility of the compounds in the aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-W190939

C11-PEG9-alcohol	Biochemical Assay Reagents	Others
C11-PEG9-alcohol is a linker with an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain increases the water solubility of the compounds in the aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-W190941

C11-PEG6-alcohol 3,6,9,12,15-Pentaoxahexacosan-1-ol	Biochemical Assay Reagents	Others
C11-PEG6-alcohol (3,6,9,12,15-Pentaoxahexacosan-1-ol) is a linker with an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain increases the water solubility of the compounds in the aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-RS01694

C11orf87 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C11orf87 Human Pre-designed siRNA Set A contains three designed siRNAs for C11orf87 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C11orf87 Human Pre-designed siRNA Set A C11orf87 Human Pre-designed siRNA Set A

HY-RS01693

C11orf80 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C11orf80 Human Pre-designed siRNA Set A contains three designed siRNAs for C11orf80 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C11orf80 Human Pre-designed siRNA Set A C11orf80 Human Pre-designed siRNA Set A

HY-RS01695

C11orf96 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C11orf96 Human Pre-designed siRNA Set A contains three designed siRNAs for C11orf96 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C11orf96 Human Pre-designed siRNA Set A C11orf96 Human Pre-designed siRNA Set A

HY-RS01692

C11orf65 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C11orf65 Human Pre-designed siRNA Set A contains three designed siRNAs for C11orf65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C11orf65 Human Pre-designed siRNA Set A C11orf65 Human Pre-designed siRNA Set A

HY-124811

IRES-C11	c-Myc	Cancer
IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes .

HY-155267

*Pomalidomide-5-C11-NH2 hydrochloride*	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-5-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

HY-153337A

*Pomalidomide-C11-NH2 hydrochloride*	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .

HY-153337

*Pomalidomide-C11-NH2*	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C11-NH2 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-C11-NH2 can be connected to the ligand for protein by a linker to form PROTAC .

HY-153959

*Thalidomide-O-amido-C11-COOH*	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-O-amido-C11-COOH (compound IMiD acid 1) is an E3 ligase ligand and linker CRBN (Cereblon) conjugate. Thalidomide-O-amido-C11-COOH can be used to synthesize PROTAC that target the degradation of DOT1L .

HY-149573

*Thalidomide-4-O-C11-NH2 hydrochloride*	Ligands for E3 Ligase	Cancer
Thalidomide-4-O-C11-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .

HY-149568

*Thalidomide-5-O-C11-NH2 hydrochloride*	Ligands for E3 Ligase	Cancer
Thalidomide-5-O-C11-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .

HY-138860

*Thalidomide-O-C11-acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-O-C11-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-174087

*Thalidomide-4-OH-C11-OH*	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-4-OH-C11-OH is an E3 Ligase Ligand-Linker Conjugate, which is composed of Thalidomide-4-OH (HY-103596) and the corresponding Linker. Thalidomide-4-OH-C11-OH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules, such as PROTAC GPX4 degrader-4 (HY-174086) .

HY-148608

LysoPalloT-NH-amide-C3-ph-m-O-C11	Orphan Receptor	Inflammation/Immunology
LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist for GPR174 with an EC₅₀ of 34 nM .

HY-W800829

S-Undecyl 6-bromohexanethioate	Biochemical Assay Reagents	Others
S-Undecyl 6-bromohexanethioate is an aliphatic linker featuring a bromide, a C6 spacer, and a thioester linked to a C11 chain.

HY-113887A

11β-Prostaglandin F1β 11β-PGF1β	Drug Isomer	Endocrinology
11β-Prostaglandin F1β (11β-PGF1β) is a stereoisomer of PGF1α with inverted C-9 and C-11 hydroxyl groups .

HY-122568

STING agonist-15	STING	Cancer
STING agonist-15 (Compound STING agonist-C11) Is a STING agonist. STING agonist-15 can be used for research of cancer and immune response .

HY-W510032

9-Ethoxy-9-oxononanoic acid	Biochemical Assay Reagents	Infection
9-Ethoxy-9-oxononanoic acid is a C-11 fatty acid that has an ethyl ester group at the end of the saturated tail. The carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Azelaic Acid Monoethyl Ester has antifungal activity against Cladosporium herbarum.

HY-113465A

11-trans Leukotriene E4	Endogenous Metabolite	Inflammation/Immunology
11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum .

HY-162625

Tubulin inhibitor 47	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 47 (compound C11) is a potent tubulin inhibitor. Tubulin inhibitor 47 induces apoptosis and cell cycle arrest at the M phase. Tubulin inhibitor 47 shows anti-tumor activity .

HY-W800843

tert-Butyl 3-(7-((undecan-3-yloxy)carbonyl)heptylamino)propylcarbamate	Liposome	Cancer
tert-Butyl 3-(7-((undecan-3-yloxy)carbonyl)heptylamino)propylcarbamate is an aminolipid featuring a Boc-protected primary amine, a propylamine spacer attached to an octanoate chain and a C11 chain.

HY-W130177

Iodocholine iodide	Biochemical Assay Reagents	Cancer
Iodocholine iodide is a non-toxic, metabolizable "green" catalyst that can catalyze the free radical polymerization of functional polymers. Iodocholine iodide is also the non-radioactive iodide of Carbon-11 choline. C-11 Choline can be used in PET imaging and non-informative bone scintigraphy, CT or MRI to monitor various types of cancer .

HY-W800842

1-Ethylnonyl 8-bromooctanoate	Biochemical Assay Reagents	Others
1-Ethylnonyl 8-bromooctanoate is a lipid featuring a bromide along an octanoate chain linking to a C11 chain. 1-Ethylnonyl 8-bromooctanoate can be derivatized via substitution at the bromide leaving group.

HY-122426

1-Bromoundecane n-Undecyl bromide	Biochemical Assay Reagents	Others
1-Bromoundecane (n-Undecyl bromide) is a chemical reagent featuring a bromide along a saturated C11 chain. Bromide is easily displaced by nucleophiles such as alcohols or amines. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

HY-162506

IGF-1R inhibitor-3	IGF-1R	Cancer
IGF-1R inhibitor-3 (Compound C11) is an allosteric inhibitor for insulin-like growth factor receptor 1 kinase (IGF-1R), with an IC₅₀ of 0.2 μM .

HY-P990802

Anti-Mouse CD3ε Antibody (145-2C11)	CD3	Metabolic Disease Inflammation/Immunology
Anti-Mouse CD3ε Antibody (145-2C11) is an orally active anti-mouse CD3ε IgG1 monoclonal antibody. Anti-Mouse CD3ε Antibody (145-2C11) can inhibit the proliferation of effector T cells and improve the function of regulatory T cells (Tregs). Anti-Mouse CD3ε Antibody (145-2C11) relieves inflammatory response by inhibiting the production of pro-inflammatory cytokines and increasing the secretion of anti-inflammatory factors. Anti-Mouse CD3ε Antibody (145-2C11) can be used for research on metabolic and immune system conditions such as diabetes and lupus. The recommend isotype control of Anti-Mouse CD3ε Antibody (145-2C11): Armenian hamster IgG, Isotype Control (HY-P990305) .

HY-P5537S

ETTVFENLPEK-13C11,15N2 TFA	Isotope-Labeled Compounds	Others
ETTVFENLPEK- ¹³C₁₁, ¹⁵N₂ (TFA) (ETTVFENLPEK- ¹³C₁₁, ¹⁵N₂ (TFA)) is a ¹³C- and ¹⁵N-labeled compound.

HY-W401062

2-Undecyloxirane 1,2-Epoxytridecane	Biochemical Assay Reagents	Others
2-Undecyloxirane (1,2-Epoxytridecane) is a chemical reagent featuring an epoxy group on a C11 chain. The epoxy group undergoes ring opening in the presence of nucleophiles to form a branched structure containing a secondary alcohol. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

HY-W747563

11-trans Leukotriene D4 11-trans LTD4	Drug Isomer	Others
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.

HY-126911

11-keto Fluprostenol Fluprostenol Prostaglandin D2	Prostaglandin Receptor	Endocrinology
11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.

HY-166256

CLA 9c,11tr ethyl ester Ethyl (9Z,11E)-9,11-octadecadienoate	Biochemical Assay Reagents	Metabolic Disease
CLA 9c,11tr ethyl ester (Ethyl (9Z,11E)-9,11-octadecadienoate) is an ester product.

HY-173277

FtsZ-IN-13	Bacterial	Infection
FtsZ-IN-13 (Compound C11) is an inhibitor of temperature-sensitive mutant Z (FtsZ), with IC₅₀ values of 47.97, 34 μM against FtsZSa and FtsZPa, respectively. FtsZ-IN-13 has a notable antimicrobial activity against S. aureus (minimum inhibitory concentration value of 2 μg/mL), cystic fibrosis S. aureus clinical isolates, and methicillin-resistant S. aureus (MRSA) strains. FtsZ-IN-13 can be used for antimicrobial resistance study .

HY-146302

14-3-3η Protein inhibitor 1 2 Publications Verification	Apoptosis	Cancer
14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a K_D of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .

HY-163105

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

HY-168858

TRK-IN-30	Trk Receptor	Cancer
TRK-IN-30 (Compound C11) is the inhibitor for tropomyosin receptor kinase (TRK) that inhibits TRKA, TRKB and TRKC and drug resistant mutant TRKA ^G595R with an IC₅₀ of 1.8, 0.98, 3.8, and 54 nM, respectively. TRK-IN-30 inhibits the activation of the downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 inhibits the colony formation and cell migration of Km-12, arrests the cell cycle at G0/G1 phase, and induces apoptosis in Km-12 .

HY-N0623S2

L-Tryptophan-13C11 Tryptophan-¹³C₁₁; Tryptophane-¹³C₁₁	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹³C₁₁ is the ¹³C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .

HY-W008034S

Fmoc-L-Trp(Boc)-OH-13C11,15N2	Isotope-Labeled Compounds Amino Acid Derivatives	Cancer
Fmoc-L-Trp(Boc)-OH- ¹³C₁₁, ¹⁵N₂ is the ¹³C-labeled and ¹⁵N-labeled Fmoc-L-Trp(Boc)-OH (HY-W008034). Fmoc-L-Trp(Boc)-OH is an amino acid derivative with a protective group, which has the ability to self-assemble and form nanoparticles. Fmoc-L-Trp(Boc)-OH can be used in the study of anticancer drug delivery .

HY-114773

N-Undecanoyl-L-homoserine lactone	Biochemical Assay Reagents	Others
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.

HY-P5630

Aeschna defensin	Bacterial	Infection
Aeschna defensing is an antimicrobial peptide derived from hemolymph of dragonfly aquatic larvae. Aeschna defensing has strong activity against gram-positive bacteria .

HY-P10881

Ganipatide	Peptide-Drug Conjugates (PDCs)	Metabolic Disease
Ganipatide is a 1-31-Glucose-dependent insulinotropic polypeptide. Ganipatide is promising for research of diabetes .

HY-N0623S4

L-Tryptophan-13C11,15N2 Tryptophan-¹³C₁₁,¹⁵N₂; Tryptophane-¹³C₁₁,¹⁵N₂	Endogenous Metabolite	Metabolic Disease
L-Tryptophan- ¹³C₁₁, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .

HY-159798

NR-11c	PROTACs p38 MAPK	Cancer
NR-11c is a selective and potent p38α PROTAC degrader. NR-11c effectively degrades p38α in a variety of tumor cells. When administered intraperitoneally or intravenously to mice, NR-11c primarily acts in the liver. NR-11c can be used in cancer research. (Pink: p38α inhibitor 5 (HY-159799); Black: linker (HY-159800); Blue: VHL E3 ligase ligand (HY-112078)) .

HY-159800

6-(4-Azidobutanamido)hexanoic acid	PROTAC Linkers	Others
6-(4-Azidobutanamido) hexanoic acid is a PROTAC Linker that can be used to synthesize the PROTAC molecule NR-11c (HY-159798) .

HY-159799

p38α inhibitor 5	p38 MAPK	Cancer
p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0482

Phillyrin 5 Publications Verification	Infection Structural Classification Oleaceae Classification of Application Fields Source classification Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields	Cytochrome P450 Influenza Virus Bacterial
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities . Phillyrin has anti-influenza A virus activities .