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BI 186908

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-120847
    BI 186908

    		MCHR1 (GPR24) Neurological Disease
    BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity .
    BI 186908

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