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Results for "

BEL-7402

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) ADAMTS (1) Adrenergic Receptor (2) Akt (5) Apoptosis (5) Arf Family GTPase (2) Autophagy (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (3) Dopamine Receptor (2) Drug Derivative (2) ERK (1) HDAC (2) Histone Demethylase (2) Microtubule/Tubulin (1) MMP (2) mTOR (2) NEKs (1) NF-κB (1) PARP (1) Phosphodiesterase (PDE) (1) PI3K (3) Reactive Oxygen Species (ROS) (3) Reference Standards (1) SOD (1) TGF-beta/Smad (2) TNF Receptor (1)
By Research Areas:	Cancer (26) Endocrinology (2) Inflammation/Immunology (2) Neurological Disease (2)

By Targets:

5-HT Receptor (2)

ADAMTS (1)

Adrenergic Receptor (2)

Akt (5)

Apoptosis (5)

Arf Family GTPase (2)

Autophagy (2)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Caspase (3)

Dopamine Receptor (2)

Drug Derivative (2)

ERK (1)

HDAC (2)

Histone Demethylase (2)

Microtubule/Tubulin (1)

MMP (2)

mTOR (2)

NEKs (1)

NF-κB (1)

PARP (1)

Phosphodiesterase (PDE) (1)

PI3K (3)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

SOD (1)

TGF-beta/Smad (2)

TNF Receptor (1)

By Research Areas:

Cancer (26)

Endocrinology (2)

Inflammation/Immunology (2)

Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-N11928

Changnanic acid	Others	Cancer
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC₅₀s of 100 μM, 100 μM and 50.51 μM respectively .

HY-155695

HDAC-IN-61	HDAC	Cancer
HDAC-IN-61 (compound 12k) is a potent and orally active HDAC inhibitor. HDAC-IN-61 has anticancer active with an IC₅₀ value of 30 nM for Bel-7402 cell. HDAC-IN-61 can be used in research of cancer .

HY-N7623

Ursonic acid methyl ester	Drug Derivative	Cancer
Ursonic acid methyl ester is an esterified derivative of Ursolic acid (HY-N0140). Ursonic acid methyl ester shows growth inhibitory activity against four tumor cell lines, HL-60, BGC, Bel-7402 and Hela with ED₅₀ values of >100 µg/ml .

HY-172394

ZSNI-21	HDAC ADAMTS	Cancer
ZSNI-21 is a dual inhibitor of ADAM17 and HDAC2. ZSNI-21 effectively inhibits the proliferation of Bel-7402 cells and demonstrates significant anti-metastatic capabilities against HCC-LM3 cells. ZSNI-21 is promising for research of hepatocellular carcinoma (HCC) .

HY-177269

CHNQD-01269	Arf Family GTPase	Cancer
CHNQD-01269, a brefeldin A-cinnamate derivative, is an Arf1 inhibitor. CHNQD-01269 exhibits potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC₅₀ values of 0.29 and 0.84 μM, respectively. CHNQD-01269 is indicated for hepatocellular carcinoma (HCC) research .

HY-146467

Anticancer agent 62	Drug Derivative	Cancer
Anticancer agent 62 (compound 4c) is a potent anticancer agent. Anticancer agent 62 shows antiproliferative activity in HepG2, Bel-7402 and MCF-7 cancer cells, with IC₅₀ values of 0.019, 0.060 and 0.016 μM, respectively. Anticancer agent 62 shows effective tumor growth inhibition .

HY-144253

AKT-IN-11	Akt ERK	Cancer
AKT-IN-11 is one of the most effective antibacterial agents against human hepatoma BEL-7402 cell line with an IC₅₀ value of 1.15μM.

HY-146466

Anticancer agent 61	Others	Cancer
Anticancer agent 61 (compound 3v) is an orally active and potent anticancer agent. Anticancer agent 61 shows antiproliferative activity in HepG2, Bel-7402 and MCF-7 cancer cells, with IC₅₀ values of 1.12, 1.97 and 1.08 μM, respectively. Anticancer agent 61 shows effective tumor growth inhibition .

HY-N12128

Ophiopogonin R	Others	Cancer
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-N12253

(19R)-13-Deoxy-19-hydroxyenmein	Others	Cancer
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC₅₀ values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively .

HY-N13081

3-Oxo-cinobufagin	Others	Cancer
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .

HY-N7535

Chlorovaltrate K	Others	Cancer
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

HY-N6018

Beta-Eudesmol 1 Publications Verification	Caspase TNF Receptor SOD Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea .

HY-151461

CHNQD-01255	Arf Family GTPase	Cancer
CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy .

HY-146465

Anticancer agent 60	Microtubule/Tubulin	Cancer
Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC₅₀ = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model .

HY-144254

PI3Kδ-IN-10	PI3K Akt Apoptosis	Cancer
PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor with IC₅₀ of 2 nM. PI3Kδ-IN-10 robustly suppresses the downstream AKT pathway to induce subsequent apoptosis in hepatocellular carcinoma models .

HY-N6896R

Isoviolanthin (Standard)	Reference Standards TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase	Endocrinology Cancer
Isoviolanthin (Standard) is the analytical standard of Isoviolanthin (HY-N6896). This product is intended for research and analytical applications. Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

HY-W250111

Carboxymethyl chitosan	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family Caspase	Cancer
Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma .

HY-N6896

Isoviolanthin 1 Publications Verification	TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase	Endocrinology Cancer
Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

HY-15485

Zardaverine 1 Publications Verification	Phosphodiesterase (PDE) Apoptosis	Inflammation/Immunology Cancer
Zardaverine is an orally active and selective PDE3/4 inhibitor (IC₅₀)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma .

HY-150046

Nek2-IN-6	NEKs	Cancer
Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor .

HY-146302

14-3-3η Protein inhibitor 1 2 Publications Verification	Apoptosis	Cancer
14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a K_D of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .

HY-177268

Anticancer agent 277	Apoptosis Reactive Oxygen Species (ROS) PARP Caspase Akt	Cancer
Anticancer agent 277 (Compound 4a) is an anticancer agent. Anticancer agent 277 has cytotoxic activities against cancer cells. Anticancer agent 277 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. Anticancer agent 277 potently inhibits tumor growth in HepG2 xenograft mice model .

HY-14543R

Sertindole (Standard)	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Standard) is the analytical standard of Sertindole. This product is intended for research and analytical applications. Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

HY-14543

Sertindole 2 Publications Verification Lu 23-174	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Lu 23-174) is an orally active 5-HT_2A, 5-HT_2C, dopamine D₂, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

Cat. No.	Product Name	Type

HY-W250111

Carboxymethyl chitosan	Biochemical Assay Reagents
Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma .

Rubipodanone A	Quinones Structural Classification Classification of Application Fields Rubia podantha Source classification Rubiaceae Plants Naphthalene Quinones Disease Research Fields Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

Changnanic acid	Structural Classification Kadsura heteroclita (Roxb.) Craib Ketones, Aldehydes, Acids Source classification Plants Schisandraceae	Others
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC₅₀s of 100 μM, 100 μM and 50.51 μM respectively .

Beta-Eudesmol 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Plants Disease Research Fields	Caspase TNF Receptor SOD Reactive Oxygen Species (ROS)
Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea .

Isoviolanthin 1 Publications Verification	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase
Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

Ophiopogonin R	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Polysaccharides Liliaceae Source classification Plants Saccharides	Others
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

(19R)-13-Deoxy-19-hydroxyenmein	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Ambrosia camphorata (Greene) W.W.Payne Plants	Others
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC₅₀ values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively .

3-Oxo-cinobufagin	Structural Classification Microorganisms Source classification Steroids	Others
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .

Chlorovaltrate K	Structural Classification Valeriana jatamansi Jones Iridoids Terpenoids Source classification Plants Valerianaceae	Others
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

Isoviolanthin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Reference Standards TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase
Isoviolanthin (Standard) is the analytical standard of Isoviolanthin (HY-N6896). This product is intended for research and analytical applications. Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

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