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Results for "

ActRIIB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Small Interfering RNA (siRNA) (2) TGF-beta/Smad (3) TGF-β Receptor (3)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Metabolic Disease (5)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99355

Bimagrumab 1 Publications Verification Anti-ACVR2B Reference Antibody; BYM338	TGF-β Receptor	Metabolic Disease
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with K_Ds of 1.7 pM and 434 pM for human *ActRIIB* and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness .

HY-P99588

Stamulumab 1 Publications Verification MYO-029	TGF-β Receptor	Metabolic Disease
Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .

HY-P99818

Ramatercept ACE-031	TGF-β Receptor	Metabolic Disease
Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy .

HY-P990733

Cibotercept KER-012	TGF-beta/Smad	Inflammation/Immunology
Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH .

HY-P99720

Luspatercept 2 Publications Verification ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease Cancer
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .

HY-RS00248

ACVR2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACVR2B Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACVR2B Human Pre-designed siRNA Set A ACVR2B Human Pre-designed siRNA Set A

HY-RS00249

Acvr2b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acvr2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acvr2b Mouse Pre-designed siRNA Set A Acvr2b Mouse Pre-designed siRNA Set A

HY-P99720A

Luspatercept (mIgG2a) RAP-536	TGF-beta/Smad	Metabolic Disease
Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human *ActRIIB* linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .

Cat. No.	Product Name	Target	Research Area

HY-P99355

Bimagrumab 1 Publications Verification Anti-ACVR2B Reference Antibody; BYM338	TGF-β Receptor	Metabolic Disease
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with K_Ds of 1.7 pM and 434 pM for human *ActRIIB* and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness .

HY-P99588

Stamulumab 1 Publications Verification MYO-029	TGF-β Receptor	Metabolic Disease
Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .

HY-P99818

Ramatercept ACE-031	TGF-β Receptor	Metabolic Disease
Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy .

HY-P990733

Cibotercept KER-012	TGF-beta/Smad	Inflammation/Immunology
Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH .

HY-P99720

Luspatercept 2 Publications Verification ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease Cancer
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .

HY-P99720A

Luspatercept (mIgG2a) RAP-536	TGF-beta/Smad	Metabolic Disease
Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human *ActRIIB* linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .

Species:	Human (7) Mouse (2) Rat (1) Cynomolgus (4)
Tag:	His (7) Tag Free (2) GST (1) Fc (5)
Source:	HEK293 (10) P. pastoris (1) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P77290

	ACVR2B Protein, Cynomolgus (HEK293) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293) is produced in HEK293 cells,and consists of 116 amino acids (S28-M143).

HY-P72813

	ACVR2B Protein, Human (HEK293, Fc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Human	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134amino acids (M1-T134).

HY-P75536

	ACVR2B Protein, Mouse (HEK293, His) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Mouse	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 134 amino acids (M1-T134).

HY-P77291

	ACVR2B Protein, Cynomolgus (HEK293, Fc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 116 amino acids (S28-M143).

HY-P77292

	ACVR2B Protein, Cynomolgus (HEK293, His) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 116 amino acids (S28-M143).

HY-P75535

	ACVR2B Protein, Mouse (HEK293, His-hFc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Mouse	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His-hFc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 134 amino acids (M1-T134).

HY-P703681

	RIIB/ACVR2B Protein, Rat (HEK293, His) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; Acvr2b; ACTR-IIB	Rat	HEK293
	RIIB/ACVR2B Protein, Rat (HEK293, His) is the recombinant rat-derived RIIB/ACVR2B protein, expressed by HEK293, with C-His tag.

HY-P704344

	*Activin RIB & Activin RIIB* Protein, Human (HEK293, Fc)** Activin Receptor IB, His; ALK-4; Activin RIB; ACVR1B; ActRIIB; ActR-IIB; HTX4	Human	HEK293

HY-P704595

	RIIB/ACVR2B Protein, Human/Cynomolgus (HEK293, Fc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; Acvr2b; ACTR-IIB	Human;Cynomolgus	HEK293
	ACVR2B is a transmembrane kinase that forms the activin receptor complex and is essential for transducing activin signals. It regulates diverse processes including neuronal differentiation, hair follicle development, FSH production, wound healing, matrix production, immunosuppression, and carcinogenesis. RIIB/ACVR2B Protein, Human/Cynomolgus (HEK293, Fc) is the recombinant human/cynomolgus-derived RIIB/ACVR2B protein, expressed by HEK293, with C-hFc labeled tag.

HY-P700557

	ACVR2B Protein, Human (P. pastoris, N-His) Activin receptor type IIB; ACTR-IIB	Human	P. pastoris
	ACVR2B is a transmembrane kinase that forms the activin receptor complex and is essential for transducing activin signals. It regulates diverse processes including neuronal differentiation, hair follicle development, FSH production, wound healing, matrix production, immunosuppression, and carcinogenesis. ACVR2B Protein, Human (P. pastoris, N-His) is the recombinant human-derived ACVR2B protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P703526

	ACVR2B Protein, Human (sf9) Activin receptor type-2B; ACTR-IIB; Activin receptor type IIB	Human	Sf9 insect cells
	ACVR2B is a transmembrane kinase that forms the activin receptor complex and is essential for transducing activin signals. It regulates diverse processes including neuronal differentiation, hair follicle development, FSH production, wound healing, matrix production, immunosuppression, and carcinogenesis. ACVR2B Protein, Human (sf9) is the recombinant human-derived ACVR2B protein, expressed by Sf9 insect cells, with tag free.

HY-P7456

	ACVR2B Protein, Human (HEK293, His) rHuActivin receptor type 2B, His; ACVR-2B; Activin receptor type 2B	Human	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 116 amino acids (S19-T134).

HY-P704048

	ACVR2B Protein, Human (sf9, His, GST) Activin receptor type-2B; ACTR-IIB; Activin receptor type IIB	Human	Sf9 insect cells
	ACVR2B is a transmembrane kinase that forms the activin receptor complex and is essential for transducing activin signals. It regulates diverse processes including neuronal differentiation, hair follicle development, FSH production, wound healing, matrix production, immunosuppression, and carcinogenesis. ACVR2B Protein, Human (sf9, His, GST) is the recombinant human-derived ACVR2B protein, expressed by Sf9 insect cells, with His and GST labeled tag.

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ACVR2B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ACVR2B Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acvr2b Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Acvr2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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