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APOE3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apolipoprotein (2) Cytochrome P450 (1)
By Research Areas:	Cancer (1) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

3

Inhibitors & Agonists

6

Recombinant Proteins

1

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

EZ-482 1 Publications Verification	Apolipoprotein	Neurological Disease
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with K_ds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas .

GW273297X G297X	Cytochrome P450	Cancer
GW273297X is a CYP27A1 inhibitor. GW273297X reduces 27HC concentration in E0771 tumors in APOE3 mice. GW273297X can be used in breast cancer research .

ABCA1 inducer 1	Apolipoprotein	Neurological Disease
ABCA1 inducer 1 is a nonlipogenic ABCA1 inducer. ABCA1 inducer 1 increases ABCA1 expression, enhances apolipoprotein (APOE) lipidation and reverses multiple Alzheimer’s disease (AD) phenotypes, without increasing triglycerides in E3/4FAD mice that express human APOE 3/4 .

Species:	Human (6)
Tag:	His (3) Tag Free (2) Fc (1)
Source:	HEK293 (6)

Cat. No.	Compare	Product Name	Species	Source

	*Apolipoprotein E/APOE3* Protein, Human (HEK293, His)** rHuApolipoprotein E, His; APOE; Apolipoprotein E; APOE3	Human	HEK293
	Apolipoprotein E/ApoE3 is an apolipoprotein isoform that mediates lipid transport and plays a crucial role in lipid homeostasis in both plasma and the central nervous system by binding to LDL receptors (LDLR), LDL receptor-related proteins (LRP1, LRP2, LRP8), Very Low-Density Lipoprotein Receptor (VLDLR), and Heparin. The Apolipoprotein E/ApoE3 Protein, Human (HEK293, His) is a recombinant protein with a His tag at the N-terminus, consisting of 299 amino acids (K19-H317), and is expressed in HEK293 cells.

	*Apolipoprotein E/APOE3* Protein, Human (HEK293, hFc)** Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE3 Protein, Human (HEK293, hFc) is the recombinant human-derived Apolipoprotein E/APOE3 protein, expressed by HEK293 , with N-hFc labeled tag.

	*Apolipoprotein E/APOE3* Protein, Human (Biotinylated, HEK293, His)** Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with N-His labeled tag.

	*Apolipoprotein E/APOE2 Protein, Human (HEK293)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293

	*Apolipoprotein E/APOE2 Protein, Human (C130R, HEK293)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293

	*Apolipoprotein E/APOE2 Protein, Human (R176C, HEK293, His)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293

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Cat. No.	Product Name		Classification

GW273297X G297X		Alkynes
GW273297X is a CYP27A1 inhibitor. GW273297X reduces 27HC concentration in E0771 tumors in APOE3 mice. GW273297X can be used in breast cancer research .

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