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Results for "

AKR1C1

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

3

Natural
Products

2

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114009
    AKR1C1-IN-1
    1 Publications Verification

    		 Aldose Reductase Neurological Disease
    AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1 .
    AKR1C1-IN-1
  • HY-N0376
    Liquiritin
    Maximum Cited Publications
    10 Publications Verification

    		 Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology Cancer
    Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .
    Liquiritin
  • HY-118819
    5-Bromo-3-phenyl salicylic acid

    		Aldose Reductase Neurological Disease Cancer
    5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 140 nM .
    5-Bromo-3-phenyl salicylic acid
  • HY-RS00534
    AKR1C1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    AKR1C1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1C1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AKR1C1 Human Pre-designed siRNA Set A
    AKR1C1 Human Pre-designed siRNA Set A
  • HY-RS23471
    Akr1c1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Akr1c1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Akr1c1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Akr1c1 Rat Pre-designed siRNA Set A
    Akr1c1 Rat Pre-designed siRNA Set A
  • HY-N0376R
    Liquiritin (Standard)

    		Reference Standards Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology Cancer
    Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .
    Liquiritin (Standard)
  • HY-113850
    CPSA

    		Aldose Reductase Neurological Disease Cancer
    CPSA is a potent and competitive inhibitor against 20α-hydroxysteroid dehydrogenase (AKR1C1) with a Ki value of 0.86 nM. CPSA is promising for research of lung and endometrial cancers, premature birth and neuronal disorders .
    CPSA
  • HY-B0398AR
    Nalidixic acid sodium salt (Standard)

    		Reference Standards Bacterial Antibiotic Topoisomerase Infection
    Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .
    Nalidixic acid sodium salt (Standard)
  • HY-173132
    AKR1Cs-IN-1

    		Aldose Reductase Cancer
    AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and SP3 pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM against AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer .
    AKR1Cs-IN-1
  • HY-172598
    Keap1-Nrf2-IN-28

    		Keap1-Nrf2 Inflammation/Immunology
    Keap1-Nrf2-IN-28 (SG16) is an orally active Keap1-Nrf2 inhibitor. Keap1-Nrf2-IN-28 shows antioxidant capability and induces the upregulation of Nrf2, HO-1, GCLM, and Akr1c1. Keap1-Nrf2-IN-28 attenuates APAP (HY-66005)-induced acute liver injury .
    Keap1-Nrf2-IN-28
  • HY-131586
    3,7-Dihydroxyflavone

    Resogalangin

    		 17β-HSD Estrogen Receptor/ERR Aldose Reductase Endocrinology Cancer
    3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm .
    3,7-Dihydroxyflavone
  • HY-150644
    S07-2010
    1 Publications Verification

    		 Aldose Reductase Cancer
    S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .
    S07-2010
  • HY-163609
    PROTAC AKR1C3 degrader-1

    		PROTACs Aldose Reductase Cancer
    PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610)) .
    PROTAC AKR1C3 degrader-1
  • HY-D1341
    Coumberone
    1 Publications Verification

    		 Fluorescent Dye Cancer
    Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C .
    Coumberone

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