Search Result

Results for "

AIM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AIM2 (9) 5-HT Receptor (1) Ack1 (1) Adrenergic Receptor (1) Apoptosis (1) Aurora Kinase (3) Bacterial (2) Beta-lactamase (1) Biochemical Assay Reagents (2) CFTR (2) Chloride Channel (2) Cyclic GMP-AMP Synthase (1) Dopamine Receptor (1) HIV (2) Interleukin Related (2) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) MAP3K (1) NF-κB (3) NOD-like Receptor (NLR) (6) Nucleoside Antimetabolite/Analog (1) Parasite (1) Phosphodiesterase (PDE) (1) Pyroptosis (1) Pyruvate Kinase (2) Reference Standards (1) Sigma Receptor (1) Small Interfering RNA (siRNA) (13) STING (1) TNF Receptor (2) Toll-like Receptor (TLR) (4) Trk Receptor (1) γ-secretase (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (15) Neurological Disease (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) CpG ODNs (4) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (6) Antisense Oligonucleotides (2) siRNAs (13)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: AIM2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15290

AIM-100 3 Publications Verification	Ack1	Cancer
AIM-100 is a potent and selective Ack1 inhibitor with an IC₅₀ of 21.58 nM. AIM-100 also inhibits Tyr ²⁶⁷ phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect .

HY-172450

AIM4	Interleukin Related	Neurological Disease Inflammation/Immunology
AIM4 is a compound that can inhibit the aggregation of TDP-43. AIM4 has good biocompatibility and anti-inflammatory activity. AIM4 can be used in the research of diseases such as amyotrophic lateral sclerosis .

HY-RS17265

Cd69 Mouse Pre-designed siRNA Set A AIM; VEA; 5830438K24Rik	Small Interfering RNA (siRNA)	Others
Cd69 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd69 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd69 Mouse Pre-designed siRNA Set A Cd69 Mouse Pre-designed siRNA Set A

HY-RS03908

DNMT1 Human Pre-designed siRNA Set A AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI	Small Interfering RNA (siRNA)	Others
DNMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for DNMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DNMT1 Human Pre-designed siRNA Set A DNMT1 Human Pre-designed siRNA Set A

HY-RS02258

CD5L Human Pre-designed siRNA Set A AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA	Small Interfering RNA (siRNA)	Others
CD5L Human Pre-designed siRNA Set A contains three designed siRNAs for CD5L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD5L Human Pre-designed siRNA Set A CD5L Human Pre-designed siRNA Set A

HY-RS17034

Cd5l Mouse Pre-designed siRNA Set A 1/6; AIM; CT2; Pdp; Api6; mAIM; AAC-11; Sp-alpha	Small Interfering RNA (siRNA)	Others
Cd5l Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd5l gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd5l Mouse Pre-designed siRNA Set A Cd5l Mouse Pre-designed siRNA Set A

HY-RS02262

CD69 Human Pre-designed siRNA Set A AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26	Small Interfering RNA (siRNA)	Others
CD69 Human Pre-designed siRNA Set A contains three designed siRNAs for CD69 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD69 Human Pre-designed siRNA Set A CD69 Human Pre-designed siRNA Set A

HY-RS23024

Aim2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aim2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aim2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aim2 Rat Pre-designed siRNA Set A Aim2 Rat Pre-designed siRNA Set A

HY-RS00496

AIM2 Human Pre-designed siRNA Set A PYHIN4	Small Interfering RNA (siRNA)	Others
AIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for AIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AIM2 Human Pre-designed siRNA Set A AIM2 Human Pre-designed siRNA Set A

HY-RS16589

Aim2 Mouse Pre-designed siRNA Set A Gm1313; Ifi210	Small Interfering RNA (siRNA)	Others
Aim2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aim2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aim2 Mouse Pre-designed siRNA Set A Aim2 Mouse Pre-designed siRNA Set A

HY-RS01271

Aurkb Mouse Pre-designed siRNA Set A Aik2; AIM1; Ark2; AurB; IPL1; Stk5; AIM-1; AIRK2; STK-1; Stk12	Small Interfering RNA (siRNA) Aurora Kinase	Others
Aurkb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aurkb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurkb Mouse Pre-designed siRNA Set A Aurkb Mouse Pre-designed siRNA Set A

HY-RS06660

Ikbkb Rat Pre-designed siRNA Set A IKK2; AIM-1	Small Interfering RNA (siRNA)	Others
Ikbkb Rat Pre-designed siRNA Set A contains three designed siRNAs for Ikbkb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ikbkb Rat Pre-designed siRNA Set A Ikbkb Rat Pre-designed siRNA Set A

HY-RS01272

Aurkb Rat Pre-designed siRNA Set A AIM1; ARK-2; STK-1; Stk12	Small Interfering RNA (siRNA) Aurora Kinase	Others
Aurkb Rat Pre-designed siRNA Set A contains three designed siRNAs for Aurkb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurkb Rat Pre-designed siRNA Set A Aurkb Rat Pre-designed siRNA Set A

HY-RS01270

AURKB Human Pre-designed siRNA Set A AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2	Small Interfering RNA (siRNA) Aurora Kinase	Others
AURKB Human Pre-designed siRNA Set A contains three designed siRNAs for AURKB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AURKB Human Pre-designed siRNA Set A AURKB Human Pre-designed siRNA Set A

HY-RS13257

SLC45A2 Human Pre-designed siRNA Set A 1A1; AIM1; MATP; OCA4; SHEP5	Small Interfering RNA (siRNA)	Others
SLC45A2 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC45A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC45A2 Human Pre-designed siRNA Set A SLC45A2 Human Pre-designed siRNA Set A

HY-144226

*NLRP3/AIM2-IN-3* 5+ Cited Publications	NOD-like Receptor (NLR) AIM2 Pyroptosis	Inflammation/Immunology
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC₅₀ of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization .

HY-144223

*NLRP3/AIM2-IN-2* 1 Publications Verification	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
NLRP3/aim2-in-2 (compound 8) is a new potent inhibitor with different species-specific effects on NLRP3 and *AIM2* inflammasome dependent cell death. Its < b > IC < sub > 50 < / sub > < / b > value is 0.2392 μ M。

HY-144220

*NLRP3/AIM2-IN-1*	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3/AIM2-IN-1 is a thermal sepsis inhibitor with an < b > IC < sub > 50 < / sub > < / b > value of 3.136 ± 0.7667 μ M.

HY-130480

Fructose-arginine	AIM2	Inflammation/Immunology
Fructose-arginine, an amino-sugar, is an *AIM2* inflammasome activation inhibitor. Fructose-arginine attenuates the secretion of IL-1β, IL-18, and caspase-1, and Asc pyroptosome formation and Gsdmd cleavage resulting from AIM2 inflammasome activation .

HY-109194

Udonitrectag REC 0559	Trk Receptor	Neurological Disease
Udonitrectag (REC 0559), a low molecular weight compound that mimics NGF, aims to address the issue of NGF stability .

HY-153091

BMY 14802	Adrenergic Receptor 5-HT Receptor Sigma Receptor	Neurological Disease
BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM .

HY-155504

Metallo-β-lactamase-IN-11	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC₅₀=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and *AIM-1* by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance .

HY-12212

Omaveloxolone 15+ Cited Publications RTA 408	Keap1-Nrf2 STING Apoptosis	Inflammation/Immunology Cancer
Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.

HY-150751C

ODN TTAGGG sodium 1 Publications Verification ODN A151 sodium	AIM2 Toll-like Receptor (TLR)	Inflammation/Immunology
ODN TTAGGG sodium, inhibitory oligonucleotide (ODN), is a TLR9, *AIM2* and cGAS antagonist. ODN TTAGGG sodium is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG sodium can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-150751

ODN TTAGGG 1 Publications Verification ODN A151	Toll-like Receptor (TLR) AIM2	Inflammation/Immunology
ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a TLR9, *AIM2* and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-161669

NLRP3-IN-40	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-40 (compound 32) is an inhibitor of the inflammasome NLRP3, which blocks NLRP3 activation induced by multiple agonists without altering NLRC4 or AIM2 inflammasomes .

HY-150751A

Biotin-labeled ODN TTAGGG sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Biotin-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a TLR9, *AIM2* and cGAS antagonist. Biotin-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.

HY-150751B

FITC-labeled ODN TTAGGG sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
FITC-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a TLR9, *AIM2* and cGAS antagonist. FITC-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

HY-119608

GSK854	MAP3K	Cardiovascular Disease
GSK854 is a potent Inhibitor of Troponin I-Interacting Kinase (TNNI3K). GSK854 is a suitable lead for identifying new cardiac medicines and have been employed as in vivo tools in investigational studies aimed at defining the role of TNNI3K within heart failure .

HY-N9923

2-C-Methyl-D-erythritol 4-phosphate	Bacterial
2-C-Methyl-D-erythritol 4-phosphate is a metabolite intermediate exclusive to the non-mevalonate MEP pathway, predominantly found in prokaryotes, serving as a precursor for the synthesis of isoprenoids and non-isoprenoids, including vitamins; its absence in humans makes it a promising target for the development of bacterium-specific drugs aimed at treating infectious diseases.

HY-10016

E 2012 5+ Cited Publications	γ-secretase	Neurological Disease
E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat .

HY-111242

SV 156	Dopamine Receptor	Neurological Disease
SV 156 is a potent and selective D2 dopamine receptor antagonist, with a K_i of 2.5 nM for hD2. SV 156 has approximately 40-fold binding selectivity for D2 dopamine receptors compared to the D3 receptor subtype. SV 156 can be used for L-DOPA (HY-N0304)-associated abnormal involuntary movements (AIMs) research .

HY-E70532

Ribonuclease T2 (animal free)	Biochemical Assay Reagents	Others
Ribonuclease T2 (animal free) (EC 4.6.1.19) is a biocatalyst and a key enzyme in new biocatalyst technologies. Enzyme engineering aims to enhance enzyme reaction kinetics, substrate selectivity and activity under adverse conditions (e.g., low or high pH). By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible. This product does not contain animal-derived ingredients .

HY-N0822

Shikonin Maximum Cited Publications 46 Publications Verification C.I. 75535; Isoarnebin 4	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Cancer
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits *AIM2* inflammasome activation .

HY-138646

Poly(deoxyadenylic-thymidylic) acid sodium 1 Publications Verification Poly(dA:dT) sodium	Cyclic GMP-AMP Synthase AIM2	Infection Cancer
Polydeoxyadenylic-thymidylic acid (Poly(dA:dT)) sodium is a synthetic DNA polymer. Poly(dA:dT) sodium can be used to determine the activity of bound and free ribonucleic acid polymerase. Poly(dA:dT) sodium is recognized by multiple PRRs (cytosolic DNA sensors (CDS), including cGAS, AIM2, DAI, DDX41, IFI16, and LRRFIP1), and triggers the production of type I interferons. Poly(dA:dT) sodium can be used for the research of cancer and virus infection .

HY-120181

AGI-14100	Isocitrate Dehydrogenase (IDH)	Cancer
AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC₅₀=6 nM). The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors .

HY-118161

1-Adamantylaspartate beta-1-Adamantylaspartic acid	Biochemical Assay Reagents	Others
1-Adamantylaspartate is a newly developed β-β-1-imidopropionic acid used to synthesize the C-terminal octapeptide of the β subunit of human chorionic gonadotropin (hCG) and the hexadecapeptide of the α subunit of the insulin receptor (30-55) by conventional solution methods and solid phase methods, aiming to inhibit the formation of asparagine during the synthesis of asparagyl peptides. Studies have shown that β-β-1-imidopropionic acid is an effective protector of the β-carboxyl function of aspartic acid residues.

HY-N0822R

Shikonin (Standard) C.I. 75535 (Standard); Isoarnebin 4 (Standard)	Reference Standards Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Cancer
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-170233

NLRP3-IN-75	NOD-like Receptor (NLR) Interleukin Related NF-κB	Inflammation/Immunology
NLRP3-IN-75 is an orally active NLRP3 inhibitor. NLRP3-IN-75 suppresses IL-1β secretion (IC₅₀ = 23 nM). NLRP3-IN-75 selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 exhibits superior efficacy in acute peritonitis, diabetic kidney disease and IBD models .

HY-152670

JC2-11 1 Publications Verification	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1 .

HY-114727

PDE7-IN-4	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases .

HY-121067

Carbarsone	Parasite	Cancer
Carbarsone, also known as p-ureidobenzenearsonic acid, is historically used as an amebicide in human and veterinary medicine and extensively employed in poultry and swine feed, often in combination with antibiotics to prevent conditions like blackhead in turkeys. It exhibits relatively low acute toxicity, prompting investigations into its safety for food additives under the Federal Food, Drug, and Cosmetic Act. Studies aimed at assessing its potential carcinogenicity in laboratory animals have shown negative evidence similar to other arsanilic acid derivatives, suggesting minimal risk under chronic ingestion conditions. Metabolically, carbarsone is converted to arsanilic acid, which has been observed in preliminary studies involving dogs at high doses .

HY-15448

Tezacaftor 15+ Cited Publications VX-661	CFTR	Cancer
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-147412

Ultevursen QR-421a	Nucleoside Antimetabolite/Analog	Others
Ultevursen (QR-421a) is a single-stranded RNA based oligonucleotide that is designed to skip exon 13 in the RNA with the aim to stop vision loss in people that have retinitis pigmentosa due to a mutation in exon 13 of the USH2A gene (encoding usherin). Ultevursen sequence: (P-thio)[2′-O-(2-methoxyethyl)](A-G-m ⁵C-m ⁵U-m ⁵U-m ⁵C-G-G-A-G-A-A-A-m ⁵U-m ⁵U-m ⁵U-A-A-A-m ⁵U-m ⁵C) .

HY-121856

Flumizole	Others	Inflammation/Immunology
Flumizole, a derivative of substituted 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles, was synthesized and evaluated for its immunoregulatory and anti-inflammatory properties in animal models such as rat adjuvant-induced arthritis and mouse oxazolone-induced contact sensitivity assays. This compound class combines structural elements from flumizole and levamisole, aiming to enhance therapeutic efficacy. Symmetrically substituted 5,6-diaryl compounds with specific alkyl heteroatom or halogen substitutions showed optimal potency in the arthritis model. However, variations in activity were less consistent in the contact sensitivity assay. Flumizole and related compounds demonstrate potential as dual-action agents, targeting inflammation and immune modulation, offering promise for therapeutic development in immune-related disorders .

HY-15448S1

Tezacaftor-d6 VX-661-d₆	Isotope-Labeled Compounds CFTR	Cancer
Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

Cat. No.	Product Name

HY-L904

Drug Fragment Library

1,276 compounds

The MCE 1K Drug Fragment Library consists of 1,168 drug fragments. These drug fragments are derived from 2,946 FDA-approved drug molecules, and fragments from one drug can appear in other drugs, so these fragments are somewhat correlated with good PK/PD properties. Fragment-based screening can reserve enough chemical space for subsequent structural optimization. This compound library is an essential tool for drug screening based on FBDD (Fragment-Based Drug Discovery).

HY-L0123V

Life Chemicals CNS Focused Screening Library

30,300 compounds

The incidence and significance of central nervous system diseases are increasing at an alarming rate all over the world. Although substantial research efforts have been applied to develop new CNS-active drugs, only a few CNS disorders are addressed satisfactorily, while the remaining ones pose significant clinical challenges. Blood-brain barrier (BBB) permeability is one of the most important limiting factors in the design and development of novel CNS-targeted pharmaceuticals for the treatment of neurological disorders.

Carefully selected from the HTS Compound Collection to meet the parameters optimized for high BBB-permeability, our CNS Focused Screening Library comprising over 30,300 structurally-diverse and potentially CNS-active screening compounds. This original Screening Compound Library is aimed at supporting CNS drug design projects and HTS efforts in search for novel neurotherapeutics.

HY-L145

Antihypertensive Compound Library

765 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 765 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

HY-L054

Endoplasmic Reticulum Stress Compound Library

297 compounds

Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer.

MCE Endoplasmic Reticulum Stress Compound Library contains 297 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

HY-L175

Inflammasomes related Compound Library

108 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 108 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0822

Shikonin 45+ Cited Publications C.I. 75535; Isoarnebin 4	Quinones Structural Classification Classification of Application Fields Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae Disease Research Fields Cancer	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits *AIM2* inflammasome activation .

HY-N9923

2-C-Methyl-D-erythritol 4-phosphate	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Bacterial
2-C-Methyl-D-erythritol 4-phosphate is a metabolite intermediate exclusive to the non-mevalonate MEP pathway, predominantly found in prokaryotes, serving as a precursor for the synthesis of isoprenoids and non-isoprenoids, including vitamins; its absence in humans makes it a promising target for the development of bacterium-specific drugs aimed at treating infectious diseases.

HY-N0822R

Shikonin (Standard) C.I. 75535 (Standard); Isoarnebin 4 (Standard)	Quinones Structural Classification Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae	Reference Standards Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

Species:	Human (8) Mouse (3) Cynomolgus (1)
Tag:	His (7) Tag Free (2) Strep (1) GST (3) Fc (1) Flag (1)
Source:	HEK293 (6) Sf9 insect cells (3) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72816

	AIM2 Protein, Human (sf9, GST) Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2	Human	Sf9 insect cells
	AIM2 Protein, a member of the IFI20X/IFI16 family, exhibits potential regulatory functions in cell proliferation and tumorigenic reversion. Induced by interferon-gamma, AIM2 plays a key role in immune responses. Notably expressed in tissues like lymph node and appendix, AIM2 is a significant player in diverse cellular processes and immune-related functions. AIM2 Protein, Human (sf9, GST) is the recombinant human-derived AIM2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P74274

	CD69 Protein, Mouse (HEK293, His) Early activation antigen CD69; AIM; MLR-3; CD69; CLEC2C	Mouse	HEK293
	CD69 Protein, a signal transmitting receptor, mediates lymphocyte proliferation in NK cells, platelets, and lymphocytes. It facilitates homodimer formation through disulfide-linkage. CD69 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD69 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72713

	CD69 Protein, Human (HEK293, His) Early activation antigen CD69; AIM; MLR-3; CD69; CLEC2C	Human	HEK293
	CD69 protein, a key player in lymphocyte proliferation, acts as a signaling receptor in lymphocytes, natural killer (NK) cells, and platelets. It forms homodimers connected by disulfide bonds, highlighting its central role in cellular signaling for immune responses and platelet function. CD69 Protein, Human (HEK293, His) is the recombinant human-derived CD69 protein, expressed by HEK293 , with N-8*His labeled tag.

HY-P72717

	CD5L Protein, Mouse (HEK293, His) 2 Publications Verification CD5 antigen-like; mAIM; SP-alpha; Cd5l; AIM; API6	Mouse	HEK293
	The CD5L protein is primarily expressed by macrophages and regulates inflammatory responses in infection or atherosclerosis. CD5L is incorporated into adipocytes via CD36-mediated endocytosis, thereby inhibiting lipid droplet size and affecting lipolysis. CD5L Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD5L protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72718

	CD5L Protein, Human (HEK293, His) CD5 antigen-like; mAIM; SP-alpha; Cd5l; AIM; API6	Human	HEK293
	CD5L protein regulates lipid metabolism and lipolysis by promoting fatty acid endocytosis into adipocytes via the CD36 receptor. This process, crucial for maintaining lipid homeostasis, leads to the degradation of triacylglycerols into glycerol and free fatty acids. CD5L Protein, Human (HEK293, His) is the recombinant human-derived CD5L protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P702186

	AIM2 Protein, Human AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2	Human	E. coli
	AIM2 protein is a key sensor in the AIM2 inflammasome, which can activate the inflammasome in response to cytoplasmic dsDNA, thereby inducing pyroptosis. This complex is triggered by pathogens or injury signals and plays a critical role in innate immunity and inflammation. AIM2 Protein, Human is the recombinant human-derived AIM2 protein, expressed by E. coli , with tag free.

HY-P702187

	AIM2 Protein, Human (His) AIM2; Interferon-inducible protein AIM2; Absent in melanoma 2	Human	E. coli
	AIM2 protein is a key sensor in the AIM2 inflammasome, which can activate the inflammasome in response to cytoplasmic dsDNA, thereby inducing pyroptosis. This complex is triggered by pathogens or injury signals and plays a critical role in innate immunity and inflammation. AIM2 Protein, Human (His) is the recombinant human-derived AIM2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74275

	CD69 Protein, Mouse (HEK293, Fc) Early activation antigen CD69; AIM; MLR-3; CD69; CLEC2C	Mouse	HEK293
	CD69 Protein, a signal transmitting receptor, mediates lymphocyte proliferation in NK cells, platelets, and lymphocytes. It facilitates homodimer formation through disulfide-linkage. CD69 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD69 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P703564

	DNMT1 Protein, Human AIM; CXXC9; DNMT	Human	E. coli
	DNMT1 Protein, Human is the recombinant human-derived DNMT1, expressed by E. coli , with tag Free labeled tag.

HY-P703565

	DNMT1 Protein, Human (sf9, GST, Flag) AIM; CXXC9; DNMT	Human	Sf9 insect cells
	DNMT1 Protein, Human (sf9, GST, Flag) is the recombinant human-derived DNMT1, expressed by sf9 insect cells , with GST, Flag labeled tag.

HY-P703463

	AURB-INCENP Protein, Human (Active, sf9, GST, His, StrepⅡ) AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5	Human	Sf9 insect cells

HY-P700685

	CD69 Protein, Cynomolgus (HEK293, His) CD69; CLEC2C; EA1; BL-AC/P26; AIM; BL-AC; P26; GP32; 28; MLR-3	Cynomolgus	HEK293
	CD69 protein, a key player in lymphocyte proliferation, acts as a signaling receptor in lymphocytes, natural killer (NK) cells, and platelets. It forms homodimers connected by disulfide bonds, highlighting its central role in cellular signaling for immune responses and platelet function. CD69 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD69 protein, expressed by HEK293 , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-15448S1

Tezacaftor-d6

Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80562

	Aurora B Antibody (YA594) AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12	WB, IP	Human
	Aurora B Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 39 kDa, targeting to Aurora B. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P83816

	AIM2 Antibody (YA3513) PYHIN4	WB, ICC/IF, ELISA	Human

HY-P84218

	DNMT1 Antibody (YA3915) AIM; DNMT; MCMT; CXXC9; HSN1E	WB, IHC-P, ELISA	Human, Monkey

HY-P85045

	Aurora B Antibody (YA4737) AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12	WB, ELISA	Human

HY-P86439

	Aurora B Antibody (YA6131) AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12	WB, IHC-P, ICC/IF, IP, ELISA	Human

HY-P85004

	CD69 Antibody (YA4696) CD69; CLEC2C; Early activation antigen CD69; Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; CD antigen CD69; CD69 nanobody	ELISA	Human

HY-P85092

	CD69 Antibody (YA4784) CD69; CLEC2C; Early activation antigen CD69; Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; CD antigen CD69	WB, IHC-P, ICC/IF, FC, ELISA	Human