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AF 151

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174873
    AF151

    		PROTACs METTL3 Apoptosis Bcl-2 Family Cancer
    AF151 is a METTL3 PROTAC degrader with the DC50 of 0.43 μM in MOLM-13 cells. AF151 inhibits cell growth by significantly degrading METTL3 protein and reducing m6A levels. AF151 can induce cell apoptosis and reduce the level of Bcl-2 protein. AF151 can be used for research on cancer such as acute myeloid leukemia (AML). (Pink: METTL3 Ligand (HY-174874); Blue: VHL Ligand (HY-125845); Black: Linker; VHL Ligand+Linker (HY-174875)) .
    AF151
  • HY-174874
    POI-4

    		METTL3 Ligands for Target Protein for PROTAC Cancer
    POI-4 is a ligand for METTL3. POI-4 can be used for synthesizing PROTACs such as AF151 (HY-174873) .
    POI-4

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