Search Result

Results for "

AD mouse model

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Amyloid-β (2) Apoptosis (2) Arrestin (1) Bacterial (3) Bcl-2 Family (2) Caspase (2) Cholinesterase (ChE) (2) ERK (1) Ferroptosis (1) HDAC (1) iGluR (1) Isotope-Labeled Compounds (1) JNK (1) Mixed Lineage Kinase (1) NF-κB (2) NOD-like Receptor (NLR) (1) p38 MAPK (1) p62 (1) p97 (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) RIP kinase (1) SARS-CoV (1) STAT (1) Tau Protein (2) Trk Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (3) Neurological Disease (14)

By Targets:

5-HT Receptor (1)

Amyloid-β (2)

Apoptosis (2)

Arrestin (1)

Bacterial (3)

Bcl-2 Family (2)

Caspase (2)

Cholinesterase (ChE) (2)

ERK (1)

Ferroptosis (1)

HDAC (1)

iGluR (1)

Isotope-Labeled Compounds (1)

JNK (1)

Mixed Lineage Kinase (1)

NF-κB (2)

NOD-like Receptor (NLR) (1)

p38 MAPK (1)

p62 (1)

p97 (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

RIP kinase (1)

SARS-CoV (1)

STAT (1)

Tau Protein (2)

Trk Receptor (1)

TRP Channel (1)

By Research Areas:

Cancer (2)

Cardiovascular Disease (2)

Infection (1)

Inflammation/Immunology (3)

Neurological Disease (14)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153189

TrkB-IN-1	Trk Receptor	Neurological Disease
TrkB-IN-1 is a potent and orally active TrkB agonist and has favorable PK properties. TrkB-IN-1 reverses the cognitive defects in an AD mouse model and can be used for alzheimer’s disease research .

HY-105321

PBT 1033 PBT 2	Bacterial	Neurological Disease
PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .

HY-N2014

Verbenalin 1 Publications Verification	SARS-CoV Amyloid-β Ferroptosis Tau Protein Caspase Bcl-2 Family	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the nsp-12 protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease .

HY-149430

YIAD-0205	Amyloid-β	Neurological Disease
YIAD-0205 is an orally available Aβ(1?42) aggregation inhibitor. YIAD-0205 demonstrated in vivo efficacy in an AD transgenic mouse model with five familial AD mutations (5XFAD) .

HY-105321A

PBT 1033 hydrochloride PBT 2 hydrochloride	Bacterial	Neurological Disease
PBT 1033 hydrochloride is an orally active copper/zinc ionophore. PBT 1033 hydrochloride restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .

HY-W611371

FP802	TRP Channel iGluR	Neurological Disease
FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology .FP802 stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS) . FP802 can be used for AD and ALS research ^[1][2].

HY-178323

MW073	5-HT Receptor Arrestin	Neurological Disease
MW073 is a highly selective and orally active 5-HT2BR antagonist (IC₅₀ =70 nM). MW073 exerts its effects by concentration-dependently inhibiting receptor activity and β-arrestin-1 recruitment. MW073 ameliorates synaptic plasticity and behavioral deficits, including aggression, in Alzheimer’s disease (AD) mouse models. MW073 can be used for Alzheimer’s disease (AD) research ^[1][2].

HY-105321R

PBT 1033 (Standard) PBT 2 (Standard)	Bacterial Reference Standards	Neurological Disease
PBT 1033 (Standard) is the analytical standard of PBT 1033. This product is intended for research and analytical applications. PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .

HY-114977S

Avenanthramide A-d4	Isotope-Labeled Compounds Reactive Oxygen Species (ROS) Apoptosis	Cancer
Avenanthramide A-d₄ is the deuterium labeled Avenanthramide A (HY-114977). Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNA helicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active .

HY-149417

BChE/HDAC6-IN-1	HDAC Cholinesterase (ChE)	Neurological Disease
BChE/HDAC6-IN-1 is a potent and selective dual BChE/HDAC6 inhibitor with IC₅₀ values of 4 and 8.9 nM, respectively. BChE/HDAC6-IN-1 ameliorates the cognitive impairment in an Aβ1–42-induced mouse model and has the potental for AD research .

HY-113509B

15(R)-Lipoxin A4 15-epi-LXA4	STAT	Neurological Disease Inflammation/Immunology
15(R)-Lipoxin A4 (15-epi-LXA4) is a STAT-6 activator and a lipid-derived lipoxin-type specialized pro-resolving mediator (SPM) that plays a role in promoting inflammation resolution and regulating immune cell function. 15(R)-Lipoxin A4 can improve the phagocytic function of microglia and exhibits anti-inflammatory activity. In Alzheimer's disease (AD) mouse models, 15(R)-Lipoxin A4 improves AD-like pathology. 15(R)-Lipoxin A4 holds potential for use in inflammation and neurodegenerative disease research .

HY-N2909

Aurantiamide	NF-κB RIP kinase Mixed Lineage Kinase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models. Aurantiamide has in vivo inhibitory efficacy in acute kidney injury models such as ischemia/reperfusion, sepsis, and hypertension models .

HY-172941

VEN-02XX	NOD-like Receptor (NLR)	Neurological Disease
VEN-02XX is an orally active and brain-permeable NLRP3 inhibitor. VEN-02XX inhibits the release of IL-1β and IL-18 (IC₅₀ 0.3 and 0.28 μM, respectively). VEN-02XX restores memory and cognition, inhibits microgliosis, and reduces neuroinflammation and tau pathology in the 5XFAD/Rubicon KO mouse model. VEN-02XX may be used in the study of Alzheimer's disease (AD) .

HY-175841

Tau Protein Phosphorylation-IN-1	Tau Protein p38 MAPK NF-κB Apoptosis Bcl-2 Family ERK JNK	Neurological Disease
Tau Protein Phosphorylation-IN-1 is a tau protein phosphorylation inhibitor that potently protects PC12 cells against Aβ_25–35-induced cytotoxicity (EC₅₀ = 1.93 μM), and can penetrate the blood-brain barrier (BBB).Tau Protein Phosphorylation-IN-1 reverses the hyperphosphorylation of tau, significantly inhibits the expression of certain immune-related cytotoxic factors, suppresses the MAPK and NF-κB signaling pathways, and significantly inhibits the expression of RAGE and the apoptosis factors Bax/Bcl-2, both in vitro and in vivo. Tau Protein Phosphorylation-IN-1 relieves nerve damage, and improves learning and memory in an Alzheimer’s disease (AD) mouse model. Tau Protein Phosphorylation-IN-1 can be used for AD research .

HY-163909

AChE-IN-72	Cholinesterase (ChE)	Neurological Disease
AChE-IN-72 (Compound 13a) is an inhibitor for acetylcholinesterase (AChE) with an IC₅₀ of 0.59 μM. AChE-IN-72 inhibits BChE with an IC₅₀ of 5.02 μM. AChE-IN-72 exhibits radical scavenging with IC₅₀ of 5.88 μM. AChE-IN-72 exhibits iron-chelating property, inhibits Aβ1−42 aggregation, and inhibits NLRP3 inflammasome activation. AChE-IN-72 ameliorates memory impairment in Betaine (HY-B0710)-induced AD mouse model. AChE-IN-72 is blood-brain barrier (BBB) penetrable .

HY-174984

VCP/p97 IN-3	p97 Caspase p62	Cancer
VCP/p97 IN-3 is a VCP/p97 allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC₅₀ of 9 nM and the mutant VCP proteins with IC₅₀ of 12 nM (N660K) and 19 nM (V474A/D649A). VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2014

Verbenalin 1 Publications Verification	Infection Iridoids Classification of Application Fields Terpenoids Verbenaceae Source classification Verbena officinalis Linn. Plants Inflammation/Immunology Disease Research Fields	SARS-CoV Amyloid-β Ferroptosis Tau Protein Caspase Bcl-2 Family
Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the nsp-12 protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease .

HY-113509B

15(R)-Lipoxin A4 15-epi-LXA4	Natural Products Source classification	STAT
15(R)-Lipoxin A4 (15-epi-LXA4) is a STAT-6 activator and a lipid-derived lipoxin-type specialized pro-resolving mediator (SPM) that plays a role in promoting inflammation resolution and regulating immune cell function. 15(R)-Lipoxin A4 can improve the phagocytic function of microglia and exhibits anti-inflammatory activity. In Alzheimer's disease (AD) mouse models, 15(R)-Lipoxin A4 improves AD-like pathology. 15(R)-Lipoxin A4 holds potential for use in inflammation and neurodegenerative disease research .

HY-N2909

Aurantiamide	Alkaloids Classification of Application Fields Other Alkaloids Source classification Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	NF-κB RIP kinase Mixed Lineage Kinase
Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models. Aurantiamide has in vivo inhibitory efficacy in acute kidney injury models such as ischemia/reperfusion, sepsis, and hypertension models .

Cat. No.	Product Name	Chemical Structure

HY-114977S

Avenanthramide A-d4
Avenanthramide A-d₄ is the deuterium labeled Avenanthramide A (HY-114977). Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNA helicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active .

Avenanthramide A-d4

Avenanthramide A-d₄ is the deuterium labeled Avenanthramide A (HY-114977). Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNA helicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks