ACSL4

By Targets:	COX (1) ERK (3) Ferroptosis (7) Glutathione Peroxidase (3) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Microtubule/Tubulin (1) NF-κB (3) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Small Interfering RNA (siRNA) (4) TGF-beta/Smad (3)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Inflammation/Immunology (4) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121246

Fluorofenidone 1 Publications Verification AKF-PD	NF-κB ERK TGF-beta/Smad	Inflammation/Immunology Cancer
Fluorofenidone (AKF-PD) is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of *ACSL4, upregulates GPX4* expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

HY-RS00202

ACSL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACSL4 Human Pre-designed siRNA Set A contains three designed siRNAs for ACSL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACSL4 Human Pre-designed siRNA Set A ACSL4 Human Pre-designed siRNA Set A

HY-RS16244

Acsl4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acsl4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acsl4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acsl4 Rat Pre-designed siRNA Set A Acsl4 Rat Pre-designed siRNA Set A

HY-RS16556

Acsl4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acsl4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acsl4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acsl4 Mouse Pre-designed siRNA Set A Acsl4 Mouse Pre-designed siRNA Set A

HY-175328

LIBX-A403	Ferroptosis	Neurological Disease Cancer
LIBX-A403 (Compound 21) is a highly selective acyl-CoA synthetase long-chain family member 4 (ACSL4) inhibitor (IC₅₀=0.049 μM). LIBX-A403 blocks ACSL4-mediated ferroptosis-promoting phospholipid remodeling. LIBX-A403 is promising for research of cancers (e.g., triple-negative breast cancer) and neurodegenerative diseases (e.g., Parkinson’s disease) .

HY-173432

LIBX-A401	Small Interfering RNA (siRNA)	Others
LIBX-A401 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4) (IC₅₀ = 0.38 μM). LIBX-A401 has selectivity for ACSL4 over ACSL3 (IC₅₀ over 50 μM) and PPARγ (IC₅₀ over 10 μM) .

HY-155852

Lepadin H	Ferroptosis	Others
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-155851

Lepadin E	Ferroptosis MDM-2/p53 Glutathione Peroxidase	Cancer
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-174345

Ferroptosis inducer-8	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)	Cancer
Ferroptosis inducer-8 is a ferroptosis inducer with high selectivity for other cell death mechanism. Ferroptosis inducer-8 induces ferroptosis by affecting *ACSL4, GPX4, and FTH1, thereby disrupting intracellular iron homeostasis and the GSH/GPX4 antioxidant defense system, ultimately leading to the accumulation of lipid peroxidation. Ferroptosis inducer-8 also induces ROS* production. Ferroptosis inducer-8 inhibits tumor growth and can be used for research of triple-negative breast cancer (TNBC) .

HY-175698

Ferroptosis inducer-9	Ferroptosis Microtubule/Tubulin COX Glutathione Peroxidase	Cancer
Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC₅₀ of 14 nM and inhibits [ ³H]colchicine binding. Ferroptosis inducer-9 reduces expression of *GPX4* and FTH, increases COX2 and *ACSL4, lowers GSH, NADP+, and NADPH* levels, increases LPO, MDA, and Fe(II) levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC) .

HY-121246R

Fluorofenidone (Standard)	Reference Standards NF-κB ERK TGF-beta/Smad	Inflammation/Immunology
Fluorofenidone (Standard) is the analytical standard of Fluorofenidone (AKF-PD) (HY-121246). This product is intended for research and analytical applications. Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of *ACSL4, upregulates GPX4* expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

HY-115701

1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE	Ferroptosis	Inflammation/Immunology
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.

HY-121246S

Fluorofenidone-d3 AKF-PD-d₃	Isotope-Labeled Compounds NF-κB ERK TGF-beta/Smad	Inflammation/Immunology Cancer
Fluorofenidone-d₃ (AKF-PD-d3) is deuterium labeled Fluorofenidone (AKF-PD) (HY-121246). Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of *ACSL4, upregulates GPX4* expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

HY-175327

LIBX-A402	Ferroptosis	Cardiovascular Disease Neurological Disease Cancer
LIBX-A402 (Compound 15b) is a selective *ACSL4*inhibitor with an IC₅₀ of 0.33  μM. LIBX-A402 significantly protects MDA-MB-231 and LUHMES cells from ferroptosis. LIBX-A402 can be used for cancer, ischemia-reperfusion injury and neurodegenerative diseases like Parkinson’s disease research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-155852

Lepadin H	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-155851

Lepadin E	Structural Classification Alkaloids Animals Marine natural products Source classification Other marine organisms Quinoline Alkaloids	Ferroptosis MDM-2/p53 Glutathione Peroxidase
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

Cat. No.	Product Name	Chemical Structure

HY-121246S

Fluorofenidone-d3
Fluorofenidone-d₃ (AKF-PD-d3) is deuterium labeled Fluorofenidone (AKF-PD) (HY-121246). Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of *ACSL4, upregulates GPX4* expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

Fluorofenidone-d3

Fluorofenidone-d₃ (AKF-PD-d3) is deuterium labeled Fluorofenidone (AKF-PD) (HY-121246). Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P86465

	FACL4 Antibody (YA6157) Long-chain-fatty-acid--CoA ligase 4; Long-chain acyl-CoA synthetase 4; LACS 4; ACS4 antibody; ACSL 4 antibody; ACSL4 antibody	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	FACL4 Antibody (YA6157) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FACL4.

HY-P80977

	FACL4 Antibody (YA851) ACS4; FACL4; LACS4; MRX63; MRX68	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	FACL4 Antibody (YA851) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FACL4.

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Cat. No.	Product Name		Classification

HY-RS00202

ACSL4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ACSL4 Human Pre-designed siRNA Set A contains three designed siRNAs for ACSL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16244

Acsl4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Acsl4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acsl4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16556

Acsl4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Acsl4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acsl4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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