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ACAT inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (71) Apoptosis (4) Calcium Channel (1) Drug Derivative (1) Endogenous Metabolite (3) ERK (3) Fungal (1) NF-κB (1) Parasite (1) Phytohormone (1) Reference Standards (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (20) Endocrinology (1) Infection (13) Inflammation/Immunology (15) Metabolic Disease (23) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19286

Eflucimibe F 12511	Acyltransferase	Cancer
Eflucimibe (F 12511) is a new acyl-coenzyme A cholesterol O-acyltransferase (ACAT) inhibitor. Eflucimibe can be used in the research of atherosclerosis .

HY-123040

ACAT Inhibitor 1	Drug Derivative	Others
ACAT Inhibitor 1 is an active compound.

HY-N10234

Phenylpyropene A	Acyltransferase	Infection
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM .

HY-121407

Lateritin	Acyltransferase	Infection Cancer
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans .

HY-129340

AS-183	Acyltransferase	Cardiovascular Disease
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia .

HY-139024

ACAT-IN-7	Acyltransferase	Inflammation/Immunology
ACAT-IN-7 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-7 inhibits NF-κB mediated transcription .

HY-139020

ACAT-IN-3	Acyltransferase	Inflammation/Immunology
ACAT-IN-3 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-3 inhibits NF-κB mediated transcription .

HY-139025

ACAT-IN-8	Acyltransferase	Inflammation/Immunology
ACAT-IN-8 (example 206) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-8 inhibits NF-κB mediated transcription .

HY-139021A

ACAT-IN-4 hydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 hydrochloride (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 hydrochloride inhibits NF-κB mediated transcription .

HY-139021

ACAT-IN-4	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 inhibits NF-κB mediated transcription .

HY-139022

ACAT-IN-5	Acyltransferase	Inflammation/Immunology
ACAT-IN-5 (example 19) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-5 inhibits NF-κB mediated transcription .

HY-101648

ACAT-IN-1 cis isomer	Acyltransferase	Metabolic Disease
ACAT-IN-1 cis isomer is a potent *ACAT* inhibitor with an IC₅₀ of 100 nM.

HY-111880

γ-Sanshool	Acyltransferase	Cardiovascular Disease
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human *ACAT-1* and *ACAT-2* activities with IC₅₀s of 12.0 and 82.6 μM .

HY-101576

RP 70676	Acyltransferase	Metabolic Disease
RP 70676 is a potent inhibitor of *ACAT, with IC₅₀* of 25 and 44 nM for rat and rabbit ACAT.

HY-139019

ACAT-IN-2	Acyltransferase	Inflammation/Immunology
ACAT-IN-2 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 187. ACAT-IN-2 inhibits NF-κB mediated transcription .

HY-139026

ACAT-IN-9	Acyltransferase	Inflammation/Immunology
ACAT-IN-9 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 207. ACAT-IN-9 inhibits NF-κB mediated transcription .

HY-139027

ACAT-IN-10	Acyltransferase	Inflammation/Immunology
ACAT-IN-10 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 weakly inhibits NF-κB mediated transcription .

HY-139027A

ACAT-IN-10 dihydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-10 dihydrochloride is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 dihydrochloride weakly inhibits NF-κB mediated transcription .

HY-139023

ACAT-IN-6	Acyltransferase	Inflammation/Immunology
ACAT-IN-6 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 200. ACAT-IN-6 potently inhibits NF-κB mediated transcription .

HY-100400A

K-604 dihydrochloride 5 Publications Verification	Acyltransferase	Cardiovascular Disease
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC₅₀ of 0.45±0.06 μM.

HY-N14648

Purpactin B	Acyltransferase	Metabolic Disease
Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14649

Purpactin C	Acyltransferase	Metabolic Disease
Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14573

Glisoprenin B	Acyltransferase	Infection
Glisoprenin B is a cholesterol acyltransferase (ACAT) inhibitor .

HY-U00369

FCE 28654	Acyltransferase	Cardiovascular Disease
FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting *ACAT* in microsomes from rabbit aorta and intestine, and monkey liver, with IC₅₀s of 2.55, 1.08 and 5.69 μM, respcetively.

HY-13215

Avasimibe Maximum Cited Publications 9 Publications Verification CI-1011; PD-148515	Acyltransferase	Cancer
Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC₅₀s of 24 and 9.2 µM for *ACAT1* and *ACAT2*, respectively . Avasimibe can be used for the research of prostate cancer .

HY-169813

Yakuchinone B	Acyltransferase	Cardiovascular Disease
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic *ACAT* with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-100399

Nevanimibe PD-132301; ATR-101	Acyltransferase Apoptosis	Cancer
Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer .

HY-100399A

Nevanimibe hydrochloride 3 Publications Verification PD-132301 hydrochloride; ATR101 hydrochloride	Acyltransferase Apoptosis	Cancer
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer .

HY-107396

YM-750	Acyltransferase	Cardiovascular Disease
YM-750 is a potent acyl-CoA:cholesterol acyltransferase *(ACAT)* inhibitor (IC₅₀=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A .

HY-124064

TMP-153	Acyltransferase	Metabolic Disease
TMP-153 is an orally active inhibitor of *ACAT* with an IC₅₀ value of approximately 5-10 nM against hepatic and intestinal *ACAT* in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis .

HY-N14525

Glisoprenin A	Acyltransferase	Infection
Glisoprenin A is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14688

Phenylpyropene B	Acyltransferase	Inflammation/Immunology
Phenylpyropene B can inhibit ACAT activity with IC₅₀ of 12.8 μM .

HY-N14715

Gypsetin	Acyltransferase	Metabolic Disease
Gypsetin can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with an IC₅₀ of 18 μM, and its action is competitive with oleoyl-COA substrate, K_i value is 5.5 μM. Gypsetin also inhibits Oleic acid from forming cholesterol esters with an IC₅₀ of 0.65 μM .

HY-N14813

Glisoprenin D	Acyltransferase	Infection
Glisoprenin D is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14574

Glisoprenin C	Acyltransferase	Infection
Glisoprenin C is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14816

Glisoprenin E	Acyltransferase	Infection
Glisoprenin E is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-167664

KY-455	Acyltransferase	Metabolic Disease
KY-455 is a novel inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). KY-455 inhibita rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC₅₀ values of 0.4, 0.9, 2.9 and 4.1 μmol/L, respectively.

HY-N4193

Glabrol 2 Publications Verification	Acyltransferase	Cardiovascular Disease
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-100288

RP 73163 Racemate	Acyltransferase	Metabolic Disease
RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent *ACAT* inhibitor, with cholesterol lowering activity.

HY-N9552

Purpactin A	Acyltransferase	Infection
Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor found in Pen. Purpurogenum FO-6 .

HY-100400AR

K-604 dihydrochloride (Standard)	Reference Standards Acyltransferase	Cardiovascular Disease
K-604 (dihydrochloride) (Standard) is the analytical standard of K-604 (dihydrochloride). This product is intended for research and analytical applications. K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM.

HY-N10224

Terpendole C	Acyltransferase	Metabolic Disease
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-19183

E-5324	Acyltransferase	Metabolic Disease
E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC₅₀s of 44 to 190 nM.

HY-16281

Lecimibide DuP 128	Acyltransferase	Metabolic Disease
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research .

HY-N10788

Pomonic acid	Acyltransferase	Inflammation/Immunology
Pomonic acid is a triterpenoid that significantly inhibits cholesterol ester accumulation and suppresses the acyl coenzyme A:cholesterol acyltransferase (ACAT) activity .

HY-101627

YM17E	Acyltransferase	Metabolic Disease
YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC₅₀ of 44 nM in rabbit liver microsomes in vitro.

HY-16437

RP-64477	Acyltransferase	Cardiovascular Disease
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

HY-100399AR

Nevanimibe hydrochloride (Standard) PD-132301 hydrochloride (Standard); ATR101 hydrochloride (Standard)	Reference Standards Acyltransferase Apoptosis	Cancer
Nevanimibe hydrochloride (Standard) is the analytical standard of Nevanimibe hydrochloride. This product is intended for research and analytical applications. Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer .

HY-N8331

Terpendole I	Acyltransferase Endogenous Metabolite	Cancer
Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC₅₀=145 µM) .

HY-122078

FR-190809	Acyltransferase	Metabolic Disease
FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC₅₀ of 45 nM .

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ACAT inhibitor

Inhibitors & Agonists

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