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Results for "

SK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (2) Adrenergic Receptor (3) Akt (2) Aminoacyl-tRNA Synthetase (1) Amyloid-β (1) Androgen Receptor (2) Angiotensin Receptor (1) Antibiotic (2) Apoptosis (27) Atg7 (1) Atg8/LC3 (1) ATM/ATR (1) Aurora Kinase (3) Autophagy (3) Bacterial (2) Bcl-2 Family (2) Biochemical Assay Reagents (4) CaMK (1) Carbonic Anhydrase (1) Caspase (2) Cytochrome P450 (2) Dipeptidyl Peptidase (4) DNA-PK (1) DNA/RNA Synthesis (3) Dopamine Receptor (3) Drug Derivative (2) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (1) EGFR (1) Endogenous Metabolite (5) Endothelin Receptor (1) ERK (3) Fluorescent Dye (1) FOXO (1) GABA Receptor (2) Glucocorticoid Receptor (4) HDAC (1) Histamine Receptor (3) Histone Acetyltransferase (1) HMG-CoA Reductase (HMGCR) (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (1) Leukotriene Receptor (1) Ligands for Target Protein for PROTAC (1) LPL Receptor (1) MASTL (1) MDM-2/p53 (1) MicroRNA (1) Microtubule/Tubulin (5) Mitochondrial Metabolism (1) mTOR (2) Na+/K+ ATPase (1) p38 MAPK (1) PAI-1 (1) PAK (1) Parasite (2) PARP (2) PD-1/PD-L1 (1) PGE synthase (1) Phosphodiesterase (PDE) (5) PI3K (2) Potassium Channel (18) PROTACs (6) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (1) Ras (3) Reactive Oxygen Species (ROS) (2) Reference Standards (3) Ser/Thr Protease (1) Sigma Receptor (2) Sirtuin (1) Small Interfering RNA (siRNA) (1) SphK (9) STAT (1) Topoisomerase (2) TRP Channel (1) Tyrosinase (1) Vasopressin Receptor (1) Wnt (5) YTHDF (1) β-catenin (4)
By Research Areas:	Cancer (78) Cardiovascular Disease (16) Endocrinology (8) Infection (3) Inflammation/Immunology (18) Metabolic Disease (9) Neurological Disease (25)
Click Chemistry:	Azide (1)
Oligonucleotides:	Fillers (1) Human Pre-designed siRNA Sets (1) siRNAs (1)

135

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139156

SK-575	PROTACs PARP	Cancer
SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC₅₀ of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations .

HY-137341

SK-3-91	PROTACs YTHDF	Cancer
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway. SK-3-91 degrades YTHDF2. SK-3-91 inhibits cell proliferation and induces morphological changes. (Pink: TAE648 ligand (HY-169396); Blue: E3 ligase ligand (HY-131717); Black: Linker (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397)) .

HY-135732

SK33	Androgen Receptor	Cancer
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity .

HY-117059

SK609 hydrochloride	Dopamine Receptor	Neurological Disease
SK609 hydrochloride is a dopamine D3 receptor (D3R) selective agonist with an EC₅₀ of 1109 nM. SK609 hydrochloride has the potential for parkinson research .

HY-122714

SK-216	PAI-1	Cancer
SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma .

HY-101805

SK1-IN-1 2 Publications Verification	SphK	Inflammation/Immunology Cancer
SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC₅₀ of 58 nM.

HY-119016

SK1-I 1 Publications Verification BML-258	SphK CaMK	Cancer
SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a K_i value of 10 μM . SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity .

HY-121512

SK-7041	HDAC Apoptosis	Cancer
SK-7041 is a HDAC inhibitor with the IC₅₀ of 172 nM. SK-7041 induces the hyperacetylation of histones H3 and H4 .SK-7041 inhibits tumor cell growth in vivo and in vitro, induces cell apoptosis, and arrests cell cycle at the G1 phase .

HY-147101

SK-575-NEG	PARP	Cancer
SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC₅₀ of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM .

HY-W116433

SK609	Dopamine Receptor	Neurological Disease
SK609 is a selective dopamine D3 receptor agonist with activity that improves dopamine and norepinephrine levels in the cerebral cortex. SK609 has been successfully used to suppress dyskinesias in Parkinson's disease models and alleviated muscle twitches induced by L-dopa. SK609 improved performance in sustained attention tasks by significantly reducing misses and false alarms. SK609 may provide an inhibitory option for suppressing movement and cognitive impairment in patients with Parkinson's disease .

HY-174978

SK60	Isocitrate Dehydrogenase (IDH)	Others
SK60 is a dimethylated derivative of GSK321 (HY-18948) with low nanomolar potency and high selectivity for IDH1R132H (IC₅₀ = 14.5 nM). SK60 can be used as a tracer for brain imaging with the fluorescent label [ ¹⁸F] .

HY-109181

Lazuvapagon SK-1404; KRP-N118	Vasopressin Receptor	Others
Lazuvapagon (SK-1404) is a vasopressin V2 receptor agonist for the research of nocturia .

HY-147556

SK3 Channel-IN-1	Potassium Channel	Cancer
SK3 Channel-IN-1 (compound 7a) is a potent and specific SK3 channel modulator. SK3 Channel-IN-1 has efficient effect on breast cancer MDA-MB-435 cell migration while exhibiting low cytotoxicity in other cell lines. SK3 Channel-IN-1 can modulate ion channels’activity in cancer .

HY-142090

Donetidine SK&F 93574	Histamine Receptor	Others
Donetidine (SK&F 93574) is an antagonist for histamine H2 receptor, that promotes histamine release in beagle dog models .

HY-124235

SK&F 97574 hydrochloride	Na+/K+ ATPase	Others
SK&F 97574 hydrochloride is a reversible inhibitor for H+/K+ ATPase, that reduces gastric acid secretion and promotes the healing of acid-related upper gastrointestinal ulcers .

HY-14877

Anagliptin 3 Publications Verification SK-0403	Dipeptidyl Peptidase	Cardiovascular Disease Metabolic Disease
Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

HY-14877A

Anagliptin hydrochloride SK-0403 hydrochloride	Dipeptidyl Peptidase	Cardiovascular Disease Metabolic Disease
Anagliptin (SK-0403) hydrochloride is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

HY-15540

Metiamide SK&F 92058	Histamine Receptor	Endocrinology
Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.

HY-W075747

SK-J014-1n	Endogenous Metabolite Biochemical Assay Reagents
SK-J014-1n is a nickel catalyst with high cross-coupling activity. SK-J014-1n can effectively promote organic synthesis reactions and increase reaction rate and selectivity. SK-J014-1n exhibits good catalytic performance in the synthesis of complex organic molecules.

HY-W075744

SK-J002-1n	Biochemical Assay Reagents Endogenous Metabolite
SK-J002-1n is a highly efficient catalyst with excellent cross-coupling reaction activity. SK-J002-1n is widely used in organic synthesis to construct complex molecular structures. The chiral properties of SK-J002-1n make it play an important role in the pharmaceutical industry and provide support for the synthesis of chiral compounds. SK-J002-1n can significantly improve the conversion efficiency and is an important component of transition metal catalysts.

HY-171767

SK2188 JB325	PROTACs Apoptosis Caspase Aurora Kinase	Cancer
SK2188 is a highly efficient and selective PROTAC degrader targeting AURKA (DC₅₀ = 3.9 nM). SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: Thalidomide (HY-14658); Black: Linker: Amino-PEG4-alcohol (HY-W008005)) .

HY-W075745

SK-J003-1n	Others
SK-J003-1n is a nickel catalyst with excellent cross-coupling reaction activity. SK-J003-1n can be used as a ligand in organic synthesis to improve the selectivity and efficiency of the reaction. SK-J003-1n can effectively catalyze the coupling reaction between different substrates, highlighting its important role in compound development and material science.

HY-14877S1

Anagliptin-d7 SK-0403₇	Isotope-Labeled Compounds Dipeptidyl Peptidase	Cardiovascular Disease Metabolic Disease
Anagliptin-d₇ (SK-0403-d₇) is deuterium labeled Anagliptin. Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

HY-14930A

Mirodenafil dihydrochloride SK-3530 dihydrochloride	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

HY-14930

Mirodenafil SK3530	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

HY-167636

7-Hydroxy ropinirole bromide SK&F 89124 bromide	Dopamine Receptor	Cardiovascular Disease Neurological Disease
7-Hydroxy ropinirole (SK&F 89124) bromide is a potent and highly selective DA₂ receptor agonist, and a derivative of N,N-di-n-propyldopamine (DPDA). In isolated perfused rabbit ear artery models, 7-Hydroxy ropinirole (bromide) exerts its DA₂ agonist effects by inhibiting neurotransmitter release or sympathetic nerve-induced responses. It shows potential for research in the fields of cardiovascular and neurological diseases .

HY-115735

SKI-I	SphK Apoptosis	Cancer
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC₅₀ of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC₅₀=11 μM). SKI-I induces apoptosis in tumor cell lines .

HY-13822

SKI II 5+ Cited Publications	SphK Wnt Apoptosis	Cancer
SKI-II is an oral active and synthetic inhibitor of sphingosine kinase (SK) activity, with IC₅₀ values of 78 μM and 45 μM for SK1 and for SK2, respectively. SKI II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation .

HY-123024

Cefatrizine BL-S-640; SK&F 60771	Apoptosis Bacterial Antibiotic	Infection Cancer
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection .

HY-167853

KR-31080 SK-1080	Angiotensin Receptor	Metabolic Disease
KR-31080 is an derivative of imidazo [4,5-b] pyridine. KR-31080 inhibits angiotensin II receptor. KR-31080 inhibits the NO production in LPS-stimulated BV-2 cells at a concentration of 2 μm with inhibition of 8.3% .

HY-P2795

Kallikrein, Porcine pancreas kininogenase; SK-827	Endogenous Metabolite	Others
Kallikrein, Porcine pancreas (kininogenase) is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides, respectively .

HY-106785

Pobilukast SKF-104353; SK&F-104353	Leukotriene Receptor	Inflammation/Immunology
Pobilukast is a classical CysLT1 receptor antagonist. Pobilukast can be used for the research of asthma .

HY-19671

Apomine SR-45023A; SR 9223i; SK&F-99085	HMG-CoA Reductase (HMGCR) Apoptosis	Cancer
Apomine (SR-45023A) is an orally active antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer .

HY-12895

SKI V 1 Publications Verification	SphK PI3K Apoptosis	Cancer
SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC₅₀ of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC₅₀ of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity .

HY-P991600

Anti-IL-6 Antibody (Chugai SK2)	Interleukin Related	Inflammation/Immunology Cancer
Anti-IL-6 Antibody (Chugai SK2) is a murine monoclonal antibody, targeting IL-6. Anti-IL-6 Antibody (Chugai SK2) can be used for inflammatory diseases and cancers research, such as rheumatoid arthritis (RA), crohn's disease (CD) and pancreatic, lung and colon cancer .

HY-126823

Phen Green SK diacetate (5/6-mixture) 5+ Cited Publications PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe ²⁺, Cd ²⁺, Co ²⁺, Ni ²⁺, Zn ²⁺, etc. Phen green SK (PGSK) diacetate chelates Fe ²⁺, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively .

HY-N11669

Demycarosyl-3D-β-D-digitoxosylmithramycin SK	DNA/RNA Synthesis	Cancer
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .

HY-N0219

Bicuculline Maximum Cited Publications 27 Publications Verification (+)-Bicuculline	GABA Receptor	Neurological Disease
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N0219R

Bicuculline (Standard) (+)-Bicuculline (Standard)	Reference Standards GABA Receptor	Neurological Disease
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-120355A

AP14145 hydrochloride	Potassium Channel	Cardiovascular Disease
AP14145 hydrochloride is a potent K_Ca2 (SK) channel negative allosteric modulator with an IC₅₀ of 1.1 μM for K_Ca2.2 (SK2) and K_Ca2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) .

HY-109160

Rimtuzalcap 1 Publications Verification CAD-1883	Potassium Channel	Neurological Disease
Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA) .

HY-RS03787

DKK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DKK1 Human Pre-designed siRNA Set A contains three designed siRNAs for DKK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DKK1 Human Pre-designed siRNA Set A DKK1 Human Pre-designed siRNA Set A

HY-12900

RB-005	SphK	Inflammation/Immunology Cancer
RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC₅₀=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of *SK1* and SK2, which can be used in the study of inflammatory diseases and cancer .

HY-176464

GSK2220691	TRP Channel	Inflammation/Immunology
SK2220691 is a potent TRPV4 inhibitor. SK2220691 inhibits pulmonary edema induced by GSK1016790. SK2220691 inhibits HCl-induced increases in key factors such as VEGF, keratinocyte-derived chemokine (KC; CXCL1), and granulocyte colony-stimulating factor (GCSF) .

HY-110105

NS8593 hydrochloride	Potassium Channel	Neurological Disease
NS8593 hydrochloride is a potent and selective small conductance Ca ²⁺-activated K ⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits *SK3*-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the *SK1-3* subtypes Ca ²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca ²⁺), and does not affect the Ca ²⁺-activated K ⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively) .

HY-P5154

Tamapin	Potassium Channel	Neurological Disease
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of *SK2* (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-N9003

Dihydroprehelminthosporol	Others	Cancer
Dihydroprehelminthosporol (Compound 1) from the fungusVeronaea sp.of the separated. Dihydroprehelminthosporol on human cancer cell line A549 and SK-0A-3 has cytotoxicity .

HY-P5154A

Tamapin TFA	Potassium Channel	Neurological Disease
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of *SK2* (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-169396

TAE648	Ligands for Target Protein for PROTAC	Cancer
TAE648 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC SK-3-91 (HY-137341) .

HY-102070

NS13001	Potassium Channel	Neurological Disease
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC₅₀s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias .

Cat. No.	Product Name

HY-L009

Kinase Inhibitor Library

3,312 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3,312 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

HY-L009M

Kinase Inhibitor Library Mini

268 compounds

Kinases is a class of enzymes that adds chemicals called phosphates to other molecules, such as sugars or proteins. Protein phosphorylation serves as a critical regulatory mechanism for numerous cellular processes including cell division, metabolism, and signal transduction, with approximately 50% of cellular functions in humans being regulated by kinase activity. In drug discovery, kinases represent a major category of therapeutic targets, and kinase inhibitors constitute an important class of pharmaceuticals that block the activity of specific disease-associated enzymes, particularly in cancer and inflammatory disorders. Small molecule kinase inhibitors represent one of the fastest-growing drug categories, having received U.S. Food and Drug Administration (FDA) approval for both oncological and non-oncological indications. As of September 2023, over 70 FDA-approved small molecule kinase inhibitors are commercially available.

The MCE Kinase Inhibitor Library Mini contains 268 kinase inhibitors primarily targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.), and carbohydrate kinases. This collection includes 1-3 highly specific representative compounds per target, optimized for screening of kinase-related drug targets in pharmaceutical research.

Cat. No.	Product Name	Target	Research Area

HY-P5154A

Tamapin TFA	Potassium Channel	Neurological Disease
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of *SK2* (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P0256

Apamin 5+ Cited Publications Apamine	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

HY-P0256A

Apamin TFA 5+ Cited Publications Apamine TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

HY-P1424A

Lei-Dab7 TFA	Potassium Channel	Neurological Disease
Lei-Dab7 TFA is a high affinity, selective K_Ca2.2 (SK2) channel blocker (K_d=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for K_Ca2.2 over K_Ca2.1, K_Ca2.3, K_Ca3.1, K_v and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.

HY-P10761

DPI-4452	Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase	Cancer
DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC₅₀ for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P5436

SK-MLCK M13	Peptides	Others
SK-MLCK M13 is a biological active peptide. (M-13 is a peptide that represents CAM-binding domain of Calmodulin (CaM) target proteins. CaM is an ubiquitous Ca2+ binding protein.)

HY-P5154

Tamapin	Potassium Channel	Neurological Disease
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of *SK2* (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P3064

Scyllatoxin Leiurotoxin I	Potassium Channel	Neurological Disease
Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance K_Ca (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo .

HY-P1424

Lei-Dab7	Potassium Channel	Neurological Disease
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels .

HY-P10393

ERα17p ERα (295-311)	Apoptosis	Cancer
ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces apoptosis, and inhibits tumor growth in mouse models .

Cat. No.	Product Name	Target	Research Area

HY-P991600

Anti-IL-6 Antibody (Chugai SK2)	Interleukin Related	Inflammation/Immunology Cancer
Anti-IL-6 Antibody (Chugai SK2) is a murine monoclonal antibody, targeting IL-6. Anti-IL-6 Antibody (Chugai SK2) can be used for inflammatory diseases and cancers research, such as rheumatoid arthritis (RA), crohn's disease (CD) and pancreatic, lung and colon cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0219

Bicuculline 25+ Cited Publications (+)-Bicuculline	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	GABA Receptor
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N11669

Demycarosyl-3D-β-D-digitoxosylmithramycin SK	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .

HY-N0219R

Bicuculline (Standard) (+)-Bicuculline (Standard)	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	Reference Standards GABA Receptor
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N9003

Dihydroprehelminthosporol	Structural Classification Natural Products Microorganisms Source classification	Others
Dihydroprehelminthosporol (Compound 1) from the fungusVeronaea sp.of the separated. Dihydroprehelminthosporol on human cancer cell line A549 and SK-0A-3 has cytotoxicity .

HY-N6578

3-epi-Isocucurbitacin B	Structural Classification Natural Products Source classification Cucurbitaceae Trichosanthes kirilowii Maxim. Plants	Others
3-epi-Isocucurbitacin B (Compound 5) is a cucurbitane triterpene derived from Trichosanthes kirilowii. 3-epi-Isocucurbitacin B shows significant cytotoxicity to human tumor cells A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15 .

HY-123898

Cepharadione B	Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants Piper sanctum (Miq.) Schltdl. ex C.DC.	Tyrosinase Endogenous Metabolite
Cepharadione B (compound 22) is a natural compound isolated from the leaves of Piper sanctum. Cepharadione B is a tyrosinase inhibitor with an IC₅₀ value of 170 μM, and inhibits cell growth in A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cells .

HY-N15314

Syringolin A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	MDM-2/p53 Akt Apoptosis
Syringolin A is a plant elicitor that can be produced by the plant pathogen Pseudomonas syringae pv. syringae. Syringolin A exhibits anti-proliferative activity against a variety of cancer cells (IC₅₀ for SK-N-SH, LAN-1, SKOV3 is 20-25 µM), induces apoptosis in SK-N-SH through upregulation of p53 expression and downregulation of Akt/PKB proteins .

HY-N3179

Norcepharadione B	Structural Classification Alkaloids Piperidine Alkaloids Saururaceae Houttuynia cordata Thunb. Source classification Plants	Others
Norcepharadione B is an alkaloid that can be isolated from Houttuynia cordata. Norcepharadione B exhibits moderate cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cell line with ED₅₀s of 40, 26.4, 40, 14.2 and 38.2 μg/mL, respectively .

HY-N1614

1α-Hydroxytorilin	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Umbelliferae Crepidiastrum sonchifolium (Bunge) Pak & Kawano	Others
1 α-hydroxytorilin (compound 3) is a sesquiterpenoid. 1 α-hydroxytorilin can be isolated from Torilis japonica. 1α-hydroxytorilin has cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells with ED50 values of 20.52, 18.24, 17.48, 42.54 μg/mL, respectively .

HY-N12349

Glucozaluzanin C	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Ainsliaea acerifolia Nakai Compositae	Others
Glucozaluzanin C is a lignan isolated from the MeOH extract of the roots of Ainsliaea acerifolia (Compositae). Glucozaluzanin C has ED₅₀ value of 2.45 μg/mL, 1.37μg/mL, 0.40 μg/mL, 1.41 μg/mL, 1.43 μg/mL for A549 cells, SK-OV-3 cells, SK-MEL-2 cells, XF498 cells, HCT15 cells, respectively .

HY-N1265

Scutebata A	Structural Classification Terpenoids Labiatae Sesquiterpenes Source classification Derris robusta Diterpenoids Plants	Others
Scutebata A is a diterpenoid isolated from Scutellaria barbata that exhibits antitumor activity. Scutebata A is weakly cytotoxic against SK-BR-3 with an IC₅₀ value of 15.2 μM .

HY-N3113

Panaxyne	Panax ginseng C. A. Meyer Structural Classification Natural Products Source classification Plants Araliaceae	Others
Panaxyne is a polyacetylene, that can be isolated from the roots of cultivated-wild ginseng. Panaxyne shows significant and selective cytotoxicity against SK-OV-3, with an ED₅₀ of 1.40 µM .

HY-125570

Ginsenoside Rs3	Structural Classification Polysaccharides Source classification Plants Talinaceae Saccharides Talinum paniculatum (Jacq.) Gaertn.	Apoptosis
Ginsenoside Rs3 is a natural diol-type ginseng saponin with anticancer effects. Ginsenoside Rs3 selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells .

HY-122783

Isogambogic acid	Structural Classification Xanthones Source classification Guttiferae Phenols Plants Garcinia hanburyi Hook. f.	Antibiotic
Isogambogic acid is an antibiotic and anti-cancer agent which efficiently elicit cell death in LLC and SK-LU-1 within a low micromolar range with IC₅₀s of 2.26 μM and 2.02 μM. Isogambogic acid can be used for cancer research .

HY-N7340

Withaperuvin C	Structural Classification Physalis minima Linn. Source classification Plants Solanaceae Steroids	Others
Withaperuvin C is a withanolide that can be isolated from Physalis Minima. Withaperuvin C has moderate cytotoxicity against cancer cells such as HepG2, SK-LU-1, and MCF7 cells (IC₅₀: 19.5, 14.65, 11.74 μg/mL) .

HY-N8934

6β-Hydroxytomentosin	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	Others
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines .

HY-N3028

Taccalonolide B	Structural Classification Classification of Application Fields Source classification Schizocapsa plantaginea Hance Plants Disease Research Fields Taccaceae Steroids Cancer	Microtubule/Tubulin
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-129672

Thelenotoside B 25-Dihydrostichorrenoside E	Other Terpenoids Structural Classification Animals Terpenoids Source classification	Drug Derivative
Thelenotoside B (25-Dihydrostichorrenoside E) shows strong cytotoxicities against five cancer cell lines as HepG2, KB, LNCaP, MCF7 and SK-Mel2 with the IC₅₀ values from 0.95 ± 0.08 to 1.90 ± 0.13 μM. Thelenotoside B is a triterpene tetraglycoside .

HY-N12821

visamminol-3'-O-glucoside	Structural Classification Ophryosporus axilliflorus Hieron. Source classification Umbelliferae Plants Saccharides Monosaccharides	Others
Visamminol-3'-O-glucoside (Compound 4) is a chromone glycoside, which is initially isolated from Saposhnikovia divaricata. Visamminol-3'-O-glucoside exhibits weak cytotoxicity against cancer cells PC-3, SK-OV-3 and H460, with IC₅₀s of 93.91, >100 and >100 μM, respectively .

HY-N2416

Taccalonolide A	Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities . Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-N9101

4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	Structural Classification Caprifoliaceae Source classification Lignans Phenylpropanoids Viburnum cylindricum Buch.-Ham. ex D. Don Plants	Others
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC₅₀s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .

HY-N0538

Xylitol Xylite	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Autophagy Endogenous Metabolite Bacterial Atg7 Atg8/LC3
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

HY-N12589

8-epi-Helenalin	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Piptanthus nepalensis (Hook.) D. Don	Others
8-epi-Helenalin is a semitterpene lactone with anti-tumor activity that can be isolated from Inula britannicaL. var. chinensis (Rupr.) Reg. and the ED₅₀ values of 8-epi-Helenalin for HL-60, A549, MCF7, HCT-15, SK-OV-3 and Malme-3M are 12.2 μM, 53.8 μM, 9.1 μM, 8.7 μM, 18.7 μM and 8.3 μM, respectively. 8-epi-Helenalin can be used for anti-tumor studies .

HY-N9848

2α,3α,24-Trihydroxyursa-12,20(30)-dien-28-oic acid	Triterpenes Structural Classification Terpenoids Labiatae Source classification Plants Cyrtocymura cincta var. cincta	Others
2α,3α,24-Trihydroxyursa-12,20(30)-dien-28-oic acid is a triterpenoid with anticancer effects. 2α,3α,24-Trihydroxyursa-12,20(30)-dien-28-oic acid inhibits HepG2, A549, MCF-7, SK-OV-3, and HeLa cells with IC₅₀ values of 19.62 μM, 18.86 μM, 45.94 μM, 62.41 μM, and 28.74 μM, respectively .

Species:	Human (18) Virus (1) Rhesus Macaque (3) Mouse (2) Cynomolgus (1)
Tag:	His (13) Tag Free (3) Avi (9) Fc (8) B2M (1)
Source:	HEK293 (19) CHO (1) Sf9 insect cells (2) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7155B

	DKK-1 Protein, Human (HEK293) rHuDKK-1; hDkk-1; SK	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization.In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Human (HEK293) is the recombinant human-derived DKK-1 protein, expressed by HEK293 , with tag free.

HY-P7155A

	DKK-1 Protein, Human (HEK293, His) Maximum Cited Publications 10 Publications Verification rHuDKK-1; hDkk-1; SK	Human	HEK293
	Dkk-1 Protein, Human (HEK293) is involved in embryonic development through its inhibition of the Wnt signaling pathway.

HY-P71792

	TYR Protein, Human (P.pastoris, His) 2 Publications Verification ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	P. pastoris
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (P.pastoris, His) is the recombinant human-derived TYR protein, expressed by P. pastoris , with N-His, N-6*His labeled tag.

HY-P72968

	DKK-1 Protein, Human (HEK293, Fc) 3 Publications Verification Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization.In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity.DKK-1 Protein, Human (HEK293, Fc) is the recombinant human-derived DKK-1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72969

	DKK-1 Protein, Mouse (HEK293, His) Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Mouse	HEK293
	DKK-1 protein antagonizes canonical Wnt signaling by inhibiting LRP5/6-Wnt interaction and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization. In addition to its Wnt-dependent role, DKK1 has Wnt-independent anti-apoptotic activity by inhibiting the pro-apoptotic function of KREMEN1. DKK-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DKK1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75708

	DKK-1 Protein, Rhesus Macaque (HEK293, Fc) Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Rhesus Macaque	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived DKK-1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P78887

	DKK-1 Protein, Human (Biotinylated, HEK293, Fc-Avi) DKK1; SK	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived DKK-1 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of DKK-1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 235 a.a., with molecular weight of 66-80 kDa.

HY-P702913

	SPHK2 Protein, Human (sf9, His) SK2; Sphingosine kinase 2	Human	Sf9 insect cells
	SPHK2 Protein, Human (sf9, His) is the recombinant human-derived SPHK2, expressed by Sf9 insect cells , with N-6*His labeled tag. ,

HY-P79018

	TYR Protein, Human (HEK293, His) ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	HEK293
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (HEK293, His) is the recombinant human-derived TYR protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P703805

	DKK1 Protein, Rhesus macaque (HEK293, His) Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Cynomolgus;Rhesus Macaque	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK1 Protein, Rhesus macaque (HEK293, His) is the recombinant cynomolgus/rhesus macaque-derived DKK1 protein, expressed by HEK293, with C-His labeled tag.

HY-P75707

	DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, His) Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1	Rhesus Macaque	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization. In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Rhesus Macaque (N256Q, HEK293, His) is the recombinant Rhesus Macaque-derived DKK-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700940

	*HLA-A0201 MART-1 Complex Protein, Human (ELAGIGILTV, HEK293, His-Avi)** MART1; LB39-AA; SK29-AA; Melan-A; MLANA	Human	HEK293
	The HLA-A0201 MAGE-A4 complex protein is a member of the major histocompatibility complex (MHC) class I family. HLA-A0201 MART-1 Complex Protein, Human (ELAGIGILTV, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 MART-1 Complex protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A0201 MART-1 Complex Protein, Human (ELAGIGILTV, HEK293, His-Avi), has molecular weight of 53-63 kDa.

HY-P700941

	*HLA-A0201 MART-1 Complex Tetramer Protein, Human (ELAGIGILTV, HEK293, His-Avi)** MART1; LB39-AA; SK29-AA; Melan-A; MLANA	Human	HEK293
	The HLA-A0201 MAGE-A4 complex protein is a member of the major histocompatibility complex (MHC) class I family. HLA-A0201 MART-1 Complex Tetramer Protein, Human (ELAGIGILTV, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 MART-1 Complex Tetramer protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A0201 MART-1 Complex Tetramer Protein, Human (ELAGIGILTV, HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P700863

	DKK-1 Protein, Human (89a.a, HEK293, mFc) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization.In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity. DKK-1 Protein, Human (89a.a, HEK293, mFc) is the recombinant human-derived DKK1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P7154

	DKK-1 Protein, Mouse (CHO) 5 Publications Verification rMuDKK-1; mDkk-1; Dickkopf-1	Mouse	CHO
	Dkk-1 Protein, Mouse (CHO) is shown to be a potent inhibitor of Wnt signaling and member of dickkopf family.

HY-P700704

	DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization.In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity.DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived DKK-1 C terminal Domain protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P700705

	DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization.In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity.DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived DKK-1 N terminal Domain protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P700884

	DKK-1 C terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization.In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity.DKK-1 C terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived DKK-1 C terminal protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P700885

	DKK-1 N terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas are potent antagonists of canonical Wnt signaling, inhibiting LRP5/6-Wnt interactions and forming a ternary complex with KREMEN to promote LRP5/6 internalization.In addition to its proapoptotic function by antagonizing KREMEN1 independently of Wnt, DKK-1 also exhibits antiapoptotic activity.DKK-1 N terminal Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived DKK-1 N terminal protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P702765

	SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, 363a.a) SK1; sphingosine kinase 1; SPHK1; SPK 1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, 363a.a) is the recombinant human-derived SPHK1/Sphingosine Kinase 1, expressed by Sf9 insect cells, with tag Free labeled tag.

HY-P74923

	HA1/Hemagglutinin Protein, H7N3 (ACA25329, HEK293, His) Influenza A H7N3 (A/chicken/SK/HR-00011/2007) Hemagglutinin / HA1 Protein (His)	Virus	HEK293
	The hemagglutinin HA1 protein is essential for attachment of virions to host cells by binding to sialic acid-containing receptors, inducing virion internalization via clathrin-dependent or clathrin- and caveolin-independent pathways.As a class I viral fusion protein, HA1 determines host range restriction and virulence, mediating fusion between the virion membrane and the endosomal membrane.HA1/Hemagglutinin Protein, H7N3 (ACA25329, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P71544

	MLANA Protein, Human (His, B2M) Antigen LB39 AA; Antigen LB39-AA; Antigen SK29 AA; Antigen SK29-AA; MAR1_HUMAN; MART 1; MART-1; MART1; Melan A; Melan A protein; Melanoma antigen recognized by T cells 1; Melanoma antigen recognized by T-cells 1; MLAN A; MLANA; OTTHUMP00000021036; OTTHUMP00000021037; OTTHUMP00000021038; Protein Melan-A	Human	E. coli
	The MLANA protein is essential in melanosome biosynthesis, ensuring the stability of GPR143, and plays a key role in the expression, stability, transport, and processing of the melanocyte protein PMEL. Its interaction with PMEL and GPR143 highlights its integral role in the complex network required for second-stage melanosome formation. MLANA Protein, Human (His, B2M) is the recombinant human-derived MLANA protein, expressed by E. coli , with N-His, B2M labeled tag.

HY-P78494

	Nectin-1 Protein, Human (HEK293, His-Avi) CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR	Human	HEK293
	Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78179

	Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR	Human	HEK293
	Nectin-1 Protein mediates cell-cell contacts through homophilic or heterophilic trans-dimer formation, engaging in heterophilic interactions with Nectin-3 and Nectin-4. It also promotes neurite outgrowth. In microbial infection, Nectin-1 serves as a receptor for herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV). Nectin-1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-1 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-14877S1

Anagliptin-d7
Anagliptin-d₇ (SK-0403-d₇) is deuterium labeled Anagliptin. Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P86053

	Tyrosinase Antibody (YA5745) ATN; CMM8; LB24 AB; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; TYRO_HUMAN; tyrosinase; oculocutaneous albinism IA; Tyrosinase	IHC-P, ICC/IF, ELISA	Human
	Tyrosinase Antibody (YA5745) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Tyrosinase. It can be applicated for IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P82777

	Tyrosinase Antibody (YA2522) ATN; CMM8; LB24 AB; SHEP3; SK29 AB; Tumor rejection antigen AB; TYR	WB, IHC-P, ICC/IF	Human
	Tyrosinase Antibody (YA2522) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2522), targeting Tyrosinase, with a predicted molecular weight of 60 kDa (observed band size: 70-80 kDa). Tyrosinase Antibody (YA2522) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P85786

	SphK2 Antibody (YA5478) Sphingosine kinase 2; SK 2; SPK 2;	WB, IHC-P	Human, Mouse, Rat
	SphK2 Antibody (YA5478) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SphK2. It can be applicated for WB, IHC-P assays, in the background of human, mouse, rat.

HY-P85966

	Tyrosinase Antibody (YA5658) ATN; CMM8; LB24 AB; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; TYRO_HUMAN; tyrosinase; oculocutaneous albinism IA; Tyrosinase	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	Tyrosinase Antibody (YA5658) is a mouse-derived and non-conjugated IgA monoclonal antibody, targeting to Tyrosinase. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse.

HY-P82961

	DKK1 Antibody (YA2706) DKK1; Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK	WB, IHC-P, ICC/IF, FC	Human, Rat
	DKK1 Antibody (YA2706) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2706), targeting DKK1, with a predicted molecular weight of 29 kDa (observed band size: 38 kDa). DKK1 Antibody (YA2706) can be used for WB, IHC-P, ICC/IF, FC experiment in human, rat background.

HY-P85122

	Dkk-1 Antibody (YA4814) DKK1; Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK	WB, ELISA	Human
	Dkk-1 Antibody (YA4814) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Dkk-1. It can be applicated for WB, ELISA assays, in the background of human.

HY-P83836

	KCNN4 Antibody (YA3533) IK; IK1; SK4; DHS2; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1	WB, ICC/IF, FC, ELISA	Human
	KCNN4 Antibody (YA3533) is a mouse-derived and non-conjugated IgG1 antibody, targeting to KCNN4. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

HY-P86022

	Melan-A Antibody (YA5714) Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A;	IHC-P, ELISA	Human
	Melan-A Antibody (YA5714) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Melan-A. It can be applicated for IHC-P, ELISA assays, in the background of human.

HY-P86451

	Melan-A Antibody (YA6143) Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse,
	Melan-A Antibody (YA6143) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Melan-A. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse.

HY-P83295

	MelanA Antibody (YA3040) MLANA; MART1; Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A	WB, IHC-P, ICC/IF, FC	Human
	MelanA Antibody (YA3040) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3040), targeting MelanA, with a predicted molecular weight of 13 kDa (observed band size: 20 kDa). MelanA Antibody (YA3040) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.

HY-P85918

	Melan-A Antibody (YA5610) Antigen LB39 AA; Antigen LB39-AA; Antigen SK29 AA; Antigen SK29-AA; MAR1_HUMAN; MART 1; MART-1; MART1; Melan A; Melan A protein; Melanoma antigen recognized by T cells 1; Melanoma antigen recognized by T-cells 1; MLAN A; MLANA; OTTHUMP00000021036; OTTHUMP00000021037; OTTHUMP00000021038; Protein Melan-A	IHC-P, WB, ICC/IF, ELISA	Human
	Melan-A Antibody (YA5610) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Melan-A. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.