Dkk-1 Antibody (YA4814)

Dkk-1 Antibody (YA4814) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Dkk-1. It can be applicated for WB, ELISA assays, in the background of human.

DKK1 protein serves as a potent antagonist of canonical Wnt signaling through multiple mechanisms, including inhibiting the interaction between LRP5/6 and Wnt and forming a ternary complex with the transmembrane protein KREMEN, which facilitates the internalization of LRP5/6. Additionally, DKK1 exhibits Wnt-independent anti-apoptotic activity by inhibiting the pro-apoptotic function of KREMEN1. In limb development, DKK1 plays a crucial role by attenuating Wnt signaling, contributing to normal limb patterning. The protein's interactions with LRP5, LRP6, and KREM1, especially in the presence of MESD, highlight its involvement in the intricate regulation of Wnt-mediated signaling pathways, underscoring its significance in various cellular processes and developmental contexts.

O94907

Predicted band size: 29 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of Dkk-1 expressed in E. Coli.