KCNN4 Antibody (YA3533)

Cat. No.: HY-P83836: Data Sheet User Guide for Antibodies
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KCNN4 Antibody (YA3533) is a mouse-derived and non-conjugated IgG1 antibody, targeting to KCNN4. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
Properties
Documentation

Description	KCNN4 Antibody (YA3533) is a mouse-derived and non-conjugated IgG1 antibody, targeting to KCNN4. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.
Background	The KCNN4 (Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 4) protein functions as a voltage-independent potassium channel activated by intracellular calcium, leading to membrane hyperpolarization and subsequent promotion of calcium influx. It is essential for maximal calcium influx and proliferation during the reactivation of naive T-cells, highlighting its significance in immune response modulation. Additionally, KCNN4 plays a role in the late stages of EGF-induced macropinocytosis, underscoring its involvement in cellular processes beyond ion channel activity. Notably, the channel is inhibited by clotrimazole and charybdotoxin but remains insensitive to apamin, providing insight into potential pharmacological interventions for modulating KCNN4 function.
Gene ID	3783 [NCBI]
SwissProt ID	O15554
Synonyms	IK; IK1; SK4; DHS2; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1
Molecular Weight	Predicted band size: 47.6 kDa; Observed band size: 45 kDa
Purity	affinity purified.
Conjugation	Non-conjugated
Product Categories	Primary Antibody; Mouse Monoclonal Antibody
Host	Mouse
Reactivity	Human
Dilution Ratio	WB: 1/500-1/2000; IF: 1/50-1/200; FC: 1/200-1/400; ELISA: 1/10000
Application	WB, ICC/IF, FC, ELISA
Appearance	Liquid
Formulation	Supplied in PBS with 0.05% sodium azide
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG1
Immunogen	Purified recombinant fragment of human KCNN4 (AA: extra 286-427) expressed in E. Coli.
Documentation	Data Sheet (234 KB) User Guide for Antibodies (1077 KB)

KCNN4 Antibody (YA3533) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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KCNN4 Antibody (YA3533)

Biological Activity

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KCNN4 Antibody (YA3533) Related Classifications

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