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α-Lipoic Acid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (5) Biochemical Assay Reagents (2) Endogenous Metabolite (8) GLUT (1) HIV (5) Insulin Receptor (1) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (8) NF-κB (5) PROTAC Linkers (1) Reactive Oxygen Species (ROS) (3) Reference Standards (4) TrxR (1) Tyrosinase (1)
By Research Areas:	Cancer (10) Infection (5) Inflammation/Immunology (8) Metabolic Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Amino acid Transporter Amino Acid Derivatives Amino Acid Decarboxylase Hydroxycarboxylic Acid Receptor (HCAR) Amino Acid Oxidase Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0492

α-Lipoic Acid Maximum Cited Publications 8 Publications Verification Thioctic Acid; (±)-α-Lipoic Acid; DL-α-Lipoic Acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium Maximum Cited Publications 8 Publications Verification Thioctic Acid sodium; (±)-α-Lipoic Acid sodium; DL-α-Lipoic Acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492R

α-Lipoic Acid (Standard) Maximum Cited Publications 8 Publications Verification Thioctic Acid (Standard); (±)-α-Lipoic Acid (Standard); DL-α-Lipoic Acid (Standard)	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-141336

α-Lipoic acid-NHS 3 Publications Verification DL-α-Lipoic Acid-NHS	PROTAC Linkers	Cancer
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-N0492S

α-Lipoic Acid-d5 Thioctic Acid-d₅; (±)-α-Lipoic Acid-d₅; DL-α-Lipoic Acid-d₅	Isotope-Labeled Compounds NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells .

HY-18733

Lipoic acid Maximum Cited Publications 8 Publications Verification (R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid	Endogenous Metabolite Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Inflammation/Immunology Cancer
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-134633

Alpha-lipoic acid choline ester chloride EV 06 chloride; UNR 844 chloride	Others	Others
Alpha-lipoic acid choline ester (chloride) is a type of choline ester of alpha-lipoic acid. Alpha-lipoic acid choline ester (chloride) can reduce protein disulfides and increase the elasticity of mouse lenses, making it useful for research on presbyopia .

HY-N0492AR

α-Lipoic Acid sodium (Standard) Thioctic Acid sodium (Standard); (±)-α-Lipoic Acid sodium (Standard); DL-α-Lipoic Acid sodium (Standard)	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

HY-120974

α-lipoic acid derivative 1	GLUT	Metabolic Disease
α-Lipoic Acid Derivative 1 (Compound AN-7) is an α-lipoic acid derivative that enhances glucose transport in skeletal muscle by releasing active α-lipoic acid (LA), significantly improving glucose metabolism. In L6 skeletal muscle cells, α-Lipoic Acid Derivative 1 significantly increases glucose transport rates, approximately 12 times more potent than the parent compound α-lipoic acid (HY-N0492). In a mild diabetic mouse model, 10 mg/kg of α-Lipoic Acid Derivative 1 administered for two weeks significantly reduced blood glucose levels by 39%. α-Lipoic Acid Derivative 1 shows significant potential in research related to glucose metabolism in diabetes .

HY-151802

CPUL1	TrxR	Cancer
CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective .

HY-18733R

Lipoic acid (Standard) Maximum Cited Publications 8 Publications Verification (R)-(+)-α-Lipoic Acid(Standard); R-(+)-Thioctic Acid (Standard)	Reference Standards Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-18733S

Lipoic acid-d4 (R)-(+)-α-Lipoic Acid-d₄; R-(+)-Thioctic Acid-d₄	Isotope-Labeled Compounds Endogenous Metabolite Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Lipoic acid-d₄ ((R)-(+)-α-Lipoic acid-d₄) is deuterium labeled Lipoic acid. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid .

HY-W015777

4-Methoxybenzyl alcohol P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol	Biochemical Assay Reagents	Others
4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

HY-119152

CMX-2043	Insulin Receptor Tyrosinase Akt	Others
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model .

HY-W015777R

4-Methoxybenzyl alcohol (Standard) P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)	Reference Standards Biochemical Assay Reagents	Others
4-Methoxybenzyl alcohol (Standard) is the analytical standard of 4-Methoxybenzyl alcohol. This product is intended for research and analytical applications. 4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

Cat. No.	Product Name	Type

HY-W015777

4-Methoxybenzyl alcohol P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol	Biochemical Assay Reagents
4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

HY-W015777R

4-Methoxybenzyl alcohol (Standard) P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)	Biochemical Assay Reagents
4-Methoxybenzyl alcohol (Standard) is the analytical standard of 4-Methoxybenzyl alcohol. This product is intended for research and analytical applications. 4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

4-Methoxybenzyl alcohol (Standard)

P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)

Biochemical Assay Reagents

4-Methoxybenzyl alcohol (Standard) is the analytical standard of 4-Methoxybenzyl alcohol. This product is intended for research and analytical applications. 4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .

Cat. No.	Product Name	Target	Research Area

HY-119152

CMX-2043	Insulin Receptor Tyrosinase Akt	Others
CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0492

α-Lipoic Acid Maximum Cited Publications 8 Publications Verification Thioctic Acid; (±)-α-Lipoic Acid; DL-α-Lipoic Acid	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium Maximum Cited Publications 8 Publications Verification Thioctic Acid sodium; (±)-α-Lipoic Acid sodium; DL-α-Lipoic Acid sodium	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492R

α-Lipoic Acid (Standard) Maximum Cited Publications 8 Publications Verification Thioctic Acid (Standard); (±)-α-Lipoic Acid (Standard); DL-α-Lipoic Acid (Standard)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-18733

Lipoic acid Maximum Cited Publications 8 Publications Verification (R)-(+)-α-Lipoic Acid; R-(+)-Thioctic Acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Reactive Oxygen Species (ROS) Mitochondrial Metabolism
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-18733R

Lipoic acid (Standard) Maximum Cited Publications 8 Publications Verification (R)-(+)-α-Lipoic Acid(Standard); R-(+)-Thioctic Acid (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Reference Standards Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species (ROS)
Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-N0492AR

α-Lipoic Acid sodium (Standard) Thioctic Acid sodium (Standard); (±)-α-Lipoic Acid sodium (Standard); DL-α-Lipoic Acid sodium (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

Cat. No.	Product Name	Chemical Structure

HY-N0492S

α-Lipoic Acid-d5
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells .

HY-18733S

Lipoic acid-d4
Lipoic acid-d₄ ((R)-(+)-α-Lipoic acid-d₄) is deuterium labeled Lipoic acid. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid .

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α-Lipoic Acid

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products