NTCP Protein, Human (HEK293)

NTCP Protein, Human (HEK293) is the recombinant human-derived NTCP, expressed by HEK293.

NTCP is a major transporter of conjugated bile salts from plasma into hepatocytes, playing a key role in the enterohepatic circulation of bile salts, which are essential for the solubilization and absorption of dietary fat and fat-soluble vitamins. Its function is strictly dependent on the extracellular presence of sodium. NTCP exhibits broad substrate specificity, transporting various bile acids (e.g., taurocholate, cholate) as well as non-bile acid organic compounds (e.g., estrone sulfate). It works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP) to ensure efficient biological recycling of bile acids during enterohepatic circulation. by similar: Its function is strictly dependent on the extracellular presence of sodium; it works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP).

Human

HEK293

Tag Free

Q14973 (M1-A349)

6554

Full Length

Greater than 90% as determined by reducing SDS-PAGE

Solution

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 150 mM NaCl, 0.005% (w/v) LMNG.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.