Lymphotactin/XCL1 Protein, Mouse

The XCL1 protein selectively attracts lymphocytes and its chemotactic effects are distinct from those of monocytes or neutrophils. XCL1 is critical in the thymus, where it mediates the accumulation of dendritic cells in the medulla and contributes significantly to the development of regulatory T cells and the establishment of self-tolerance. Lymphotactin/XCL1 Protein, Mouse is the recombinant mouse-derived Lymphotactin/XCL1 protein, expressed by E. coli, with tag free.

XCL1 protein exhibits chemotactic activity specifically for lymphocytes, distinguishing its effect from monocytes or neutrophils. Within the thymus, XCL1 plays a pivotal role in mediating the medullary accumulation of thymic dendritic cells. This involvement contributes significantly to the development of regulatory T cells, thereby playing a key role in the establishment of self-tolerance. The chemotactic properties of XCL1 for lymphocytes, coupled with its impact on thymic dendritic cells and regulatory T cell development, highlight its intricate role in orchestrating immune responses within the thymic microenvironment and, ultimately, in shaping immune tolerance mechanisms.

Mouse

E. coli

Tag Free

P47993 (V22-G114)

174371

Full Length of Mature Protein

VGTEVLEESSCVNLQTQRLPVQKIKTYIIWEGAMRAVIFVTKRGLKICADPEAKWVKAAIKTVDGRASTRKNMAETVPTGAQRSTSTAITLTG

Approximately 10.1 kDa,based on SDS-PAGE under reducing conditions.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.