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  4. BTLA Protein, Cynomolgus (HEK293, His)

BTLA Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BTLA protein, expressed by HEK293, with C-His tag.

For research use only. We do not sell to patients.

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Description

BTLA Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BTLA protein, expressed by HEK293, with C-His tag.
Background

BTLA is an inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. It can interact with TNFRSF14 either in cis (on the same cell) or in trans (on other cells). In cis interactions, BTLA appears to play an immune regulatory role by inhibiting trans interactions in naive T cells to maintain a resting state. In trans interactions, it may predominate during adaptive immune responses to provide survival signals to effector T cells.
Species

Cynomolgus
Source

HEK293
Tag

C-8*His
Accession

A0A2K5W7M7 (K31-P152)
Protein Length

Partial
Predicted Molecular Mass
15 kDa
Molecular Weight

Approximately 35-40 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

BTLA Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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BTLA Protein, Cynomolgus (HEK293, His)
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