ABCG2 Protein, Human (HEK293)

ABCG2 Protein, Human (HEK293) is the recombinant human-derived ABCG2, expressed by HEK293, with tag free labeled tag.

ABCG2 is an ATP-dependent transporter with broad substrate specificity belonging to the ATP-binding cassette (ABC) family, which actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells; it is involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from mitochondria to cytosol and from cytosol to extracellular space, and also functions in the cellular export of heme; it mediates the efflux of sphingosine-1-P from cells; acts as a urate exporter involved in both renal and extrarenal urate excretion; in the kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity); is involved in the excretion of steroids such as estrone 3-sulfate (E1S), 3beta-sulfooxy-androst-5-en-17-one (DHEAS), and other sulfate conjugates; mediates the secretion of vitamins like riboflavin and biotin into milk (By similarity); extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity); plays an important role in the exclusion of xenobiotics from the brain (Probable); confers cells resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin by controlling their efflux; in the placenta, limits the penetration of drugs from the maternal plasma into the fetus (By similarity); may play a role in early stem cell self-renewal by blocking differentiation (By similarity); in inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response.

Human

HEK293

Tag Free

Q9UNQ0-1 (M1-S655)

9429

Full Length of Isoform-1

Approximately 72.5 kDa

Greater than 95% as determined by reducing SDS-PAGE

Solution

Supplied as a 0.22 μm filtered solution of 40 mM HEPES (pH 7.5), 150 mM NaCl, 0.005% (w/v) GDN.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.