2. PROTAC Immunology/Inflammation
  3. Molecular Glues IKZF Family
  4. (Rac)-BMS-986449

(R)-BMS-986449 is the racemic mixture of BMS-986449 (HY-173630). BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors.

For research use only. We do not sell to patients.

(Rac)-BMS-986449

(Rac)-BMS-986449 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-BMS-986449:

(Rac)-BMS-986449 Related Antibodies

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IKZF1 IKZF2 IKZF3 IKZF4

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Description

(R)-BMS-986449 is the racemic mixture of BMS-986449 (HY-173630). BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors[1].

Molecular Weight

396.41

Formula

C21H21FN4O3
Appearance

Solid

SMILES

NC1=NC(C2=C(C(C(N3C4CCC(NC4=O)=O)C)=C(C=C2)C3=O)F)=CC(C)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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(Rac)-BMS-986449 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-BMS-986449Molecular GluesIKZF FamilyIkaros zinc finger protein familymolecular glueHeliosEosregulatory T (Treg) cellsadvanced solid tumorsInhibitorinhibitorinhibit

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