Plonmarlimab (Synonyms: TJ003234; TJM2)

Cat. No.: HY-P99779 Purity: 99.82%: Data Sheet
COA

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Plonmarlimab (TJ003234) is an anti-GM-CSF monoclonal antibody. Plonmarlimab can be used for research of rheumatoid arthritis and COVID-19.

For research use only. We do not sell to patients.

CAS No. : 2377482-36-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Plonmarlimab (TJ003234) is an anti-GM-CSF monoclonal antibody. Plonmarlimab can be used for research of rheumatoid arthritis and COVID-19^[1]^[2].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CSF2/GM-CSF

Clinical Trial

Gene ID

1437 [NCBI]

Accession

P04141

Application

ELISA, FACS, Functional assay

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

145.95 kDa

CAS No.

2377482-36-3

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Plonmarlimab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

Human IgG1 kappa

Biological Activity

Immobilized GM-CSF Protein, Human ( HY-P7016A) can bind Plonmarlimab. The EC₅₀ for this effect is 11.95 ng/mL.

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (256 KB) SDS (251 KB)

COA (232 KB) SDS-PAGE (67 KB) SEC-HPLC (122 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Bonaventura A, et al. Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies. Front Immunol. 2020 Jul 3;11:1625. [Content Brief]

[2]. Bonam SR, et al. Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients. Cell Rep Med. 2020 May 19;1(2):100016. [Content Brief]

Plonmarlimab Related Classifications

Inflammation/Immunology Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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