2. PI3K/Akt/mTOR Cytoskeleton Cell Cycle/DNA Damage Apoptosis
  3. PI3K PAK mTOR PERK Apoptosis
  4. PI3Kα-IN-27

PI3Kα-IN-27 (Compound 50b) is an orally active PI3K-α inhibitor, with an IC50 of 40 nM. PI3Kα-IN-27 effectively inhibits PAK3, p110α, phospho-mTOR and phospho-ERK1/2. PI3Kα-IN-27 induces early Apoptosis. PI3Kα-IN-27 shows anticancer activity against pancreatic cancer, lung cancer, breast cancer.

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PI3Kα-IN-27

PI3Kα-IN-27 Chemical Structure

CAS No. : 2098649-83-1

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PI3Kα-IN-27 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

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mTOR mTORC1 mTORC2

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Description

PI3Kα-IN-27 (Compound 50b) is an orally active PI3K-α inhibitor, with an IC50 of 40 nM. PI3Kα-IN-27 effectively inhibits PAK3, p110α, phospho-mTOR and phospho-ERK1/2. PI3Kα-IN-27 induces early Apoptosis. PI3Kα-IN-27 shows anticancer activity against pancreatic cancer, lung cancer, breast cancer[1].

IC50 & Target[1]

PI3Kα

40 nM (IC50)

PAK3

 

Molecular Weight

466.60

Formula

C24H30N6O2S
CAS No.
SMILES

O=C(NC1CCN(C2=NC(N3CCOCC3)=C4C(C=CS4)=N2)CC1)NC5=CC=C(CC)C=C5
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Purity & Documentation
References
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PI3Kα-IN-27 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-272098649-83-1PI3KPAKmTORPERKApoptosisPhosphoinositide 3-kinasep21 activated kinasesMammalian target of RapamycinProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseanticancerpancreatic cancerlung cancerbreast cancerInhibitorinhibitorinhibit

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