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  3. Drug Intermediate
  4. PF-06862309

PF-06862309 is a PF-06843195 (HY-131972) phosphate ester prodrug. PF-06862309 can be hydrolyzed to PF-06843195 in the presence of alkaline phosphatase. PF-06843195 is a highly selective PI3Kα inhibitor. PF-06862309 can be used for the study of breast cancer with ER+, HER2-, and PIK3CA mutations.

For research use only. We do not sell to patients.

PF-06862309

PF-06862309 Chemical Structure

CAS No. : 2067281-52-9

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PF-06862309 Related Antibodies

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Description

PF-06862309 is a PF-06843195 (HY-131972) phosphate ester prodrug. PF-06862309 can be hydrolyzed to PF-06843195 in the presence of alkaline phosphatase. PF-06843195 is a highly selective PI3Kα inhibitor. PF-06862309 can be used for the study of breast cancer with ER+, HER2-, and PIK3CA mutations[1].

Molecular Weight

578.44

Formula

C20H26F3N8O7P
CAS No.
SMILES

O=[P](O)(O)OC[C@@](CN1C(OCC(F)F)=O)(CC1)NC2=NC(N3CCOCC3)=NC(C(C=N4)=CN=C4N)=C2F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-06862309 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-068623092067281-52-9PF06862309PF 06862309Drug IntermediateDrug Iintermediatephosphate ester prodrug of PF-06843195breast cancer with ER+HER2-and PIK3CA mutationsInhibitorinhibitorinhibit

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