2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. OPC 33540

OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies.

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OPC 33540

OPC 33540 Chemical Structure

CAS No. : 189362-27-4

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OPC 33540 Related Antibodies

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Description

OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies[1].

IC50 & Target[1]

PDE3A

0.32 nM (IC50)

PDE3B

1.5 nM (IC50)

PDEI

42.9 μM (IC50)

PDE2

52.3 μM (IC50)

PDE4

100.8 μM (IC50)

PDE7

51.3 μM (IC50)

PDE5

2.5 μM (IC50)

In Vitro

OPC-33540 (0.1-100 nM) exhibits concentration-dependent increase in platelet cAMP levels and strongly inhibits platelet aggregation induced by thrombin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OPC 33540 Related Antibodies
Molecular Weight

469.62

Formula

C27H39N3O4
CAS No.
SMILES

O=C(NCCCOC1=CC2=C(NC(C=C2)=O)C=C1)N(C3CCCCCCC3)[C@H]4[C@H](O)CCCC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OPC 33540 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OPC 33540189362-27-4OPC33540OPC-33540Phosphodiesterase (PDE)phosphodiesterase 3 inhibitorcilostamideplatelet aggregationcyclic AMPrecombinant enzymeInhibitorinhibitorinhibit

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