2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species (ROS) NF-κB Apoptosis
  4. Opc 14117

OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-κB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid (HY-100807). OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis.

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Opc 14117

Opc 14117 Chemical Structure

CAS No. : 103233-65-4

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Opc 14117 Related Antibodies

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Description

OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-κB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid (HY-100807). OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis[1][2].

Molecular Weight

437.57

Formula

C26H35N3O3
CAS No.
SMILES

OC1=C2C(CC(C)(C2NC(CN3CCN(CC3)C4=CC(OC)=CC=C4)=O)C)=C(C=C1C)C
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Opc 14117 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opc 14117103233-65-4Opc14117Opc-14117Reactive Oxygen Species (ROS)NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBCerebral contusionEdema formationTissue osmolalityCognitive behaviorFree radical scavengerRatInhibitorinhibitorinhibit

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