2. Immunology/Inflammation
  3. NOD-like Receptor (NLR) Interleukin Related
  4. NOD2 agonist 4

NOD2 agonist 4 (Compound 12b) is a potent NOD2 agonist with an EC50 of 44.1 nM. NOD2 agonist 4 induces cytokine production (MCP-1, IL-6 and IL-8) in peripheral blood mononuclear cells (PBMCs), both alone and in combination with Lipopolysaccharide (LPS) (HY-D1056). NOD2 agonist 4 can be used for the studies of NOD2-targeted immunomodulator or vaccine adjuvant.

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NOD2 agonist 4

NOD2 agonist 4 Chemical Structure

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NOD2 agonist 4 Related Antibodies

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Description

NOD2 agonist 4 (Compound 12b) is a potent NOD2 agonist with an EC50 of 44.1 nM. NOD2 agonist 4 induces cytokine production (MCP-1, IL-6 and IL-8) in peripheral blood mononuclear cells (PBMCs), both alone and in combination with Lipopolysaccharide (LPS) (HY-D1056). NOD2 agonist 4 can be used for the studies of NOD2-targeted immunomodulator or vaccine adjuvant[1].
IC50 & Target[1]

NOD2

44.1 nM (EC50)

IL-6

 

IL-8

 

Molecular Weight

585.47

Formula

C28H39FeN3O7
SMILES

[][Fe][].O=C(Cc1cccc1)NCC(N[C@@H](C(C)C)C(N[C@H](CCC(OCC)=O)C(OCC)=O)=O)=O.c2cccc2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NOD2 agonist 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOD2 agonist 4NOD-like Receptor (NLR)Interleukin RelatedILFerroceneDesmuramylpeptidesNOD2 AgonistsImmunomodulationInhibitorinhibitorinhibit

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