2. Apoptosis Autophagy Metabolic Enzyme/Protease
  3. RIP kinase Autophagy Indoleamine 2,3-Dioxygenase (IDO) Ferroptosis
  4. Necrostatin-1 (Standard)

Necrostatin-1 (Standard) is the analytical standard of Necrostatin-1. This product is intended for research and analytical applications. Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor.

For research use only. We do not sell to patients.

Necrostatin-1 (Standard) Chemical Structure

Necrostatin-1 (Standard) Chemical Structure

CAS No. : 4311-88-0

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Description
Molecular Weight

259.33

Formula

C13H13N3OS
CAS No.
SMILES

O=C(C(CC1=CNC2=C1C=CC=C2)N3)N(C)C3=S
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Necrostatin-1 (Standard) Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Necrostatin-1 (Standard)4311-88-0RIP kinaseAutophagyIndoleamine 2,3-Dioxygenase (IDO)FerroptosisReceptor-interacting protein kinasesRIPKInhibitorinhibitorinhibit

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