2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. Raf c-Met/HGFR Pim EGFR VEGFR Apoptosis
  4. Multi-target kinase-IN-8

Multi-target kinase-IN-8 is an anti-cancer agent. Multi-target kinase-IN-8 exhibits inhibitory activity against various protein kinases (B-Raf V600E (IC50 = 0.078 µg/mL), c-Met (IC50 = 0.405 µg/mL), Pim-1 (IC50 = 1.053 µg/mL), EGFR WT (IC50 = 0.177 µg/mL), VEGFR-2 (IC50 = 0.275 µg/mL)). Multi-target kinase-IN-8 can induce cell cycle arrest and promote early and late apoptosis. Multi-target kinase-IN-8 is commonly used in cancer research.

For research use only. We do not sell to patients.

Multi-target kinase-IN-8

Multi-target kinase-IN-8 Chemical Structure

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Multi-target kinase-IN-8 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

Multi-target kinase-IN-8 is an anti-cancer agent. Multi-target kinase-IN-8 exhibits inhibitory activity against various protein kinases (B-Raf V600E (IC50 = 0.078 µg/mL), c-Met (IC50 = 0.405 µg/mL), Pim-1 (IC50 = 1.053 µg/mL), EGFR WT (IC50 = 0.177 µg/mL), VEGFR-2 (IC50 = 0.275 µg/mL)). Multi-target kinase-IN-8 can induce cell cycle arrest and promote early and late apoptosis. Multi-target kinase-IN-8 is commonly used in cancer research[1].

IC50 & Target[1]

VEGFR-2

0.275 μg/mL (IC50)

BRafV600E

0.078 μg/mL (IC50)

c-Met

0.405 μg/mL (IC50)

EGFR (WT)

0.177 μg/mL (IC50)

PIM1

1.053 μg/mL (IC50)

Molecular Weight

444.49

Formula

C27H20N6O
SMILES

N1(C2=CC=CC=C2)N=C(C3=CC4=CC=CC=C4O3)C(C5CC(C6=NC7=CC=CC=C7N6)=NN5)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Multi-target kinase-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-target kinase-IN-8Rafc-Met/HGFRPimEGFRVEGFRApoptosisRaf kinasesPim kinasesEpidermal growth factor receptorErbB-1HER1Vascular endothelial growth factor receptorB-Raf V600Ec-MetPim-1VEGFR-2apoptosiscancerInhibitorinhibitorinhibit

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