2. Neuronal Signaling Stem Cell/Wnt Apoptosis
  3. γ-secretase Apoptosis
  4. MRK 003

MRK 003 is a potent, selective and orally active γ-secretase inhibitor. MRK 003 reduce brain Aβ production in vivo. MRK 003 induces caspase-dependent apoptosis and inhibits tumor cell proliferation in vivo and in vitro.

For research use only. We do not sell to patients.

MRK 003

MRK 003 Chemical Structure

CAS No. : 623165-93-5

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Description

MRK 003 is a potent, selective and orally active γ-secretase inhibitor. MRK 003 reduce brain Aβ production in vivo. MRK 003 induces caspase-dependent apoptosis and inhibits tumor cell proliferation in vivo and in vitro[1][2][3].

Cellular Effect
Cell Line Type Value Description References
SH-SY5Y IC50
0.24 nM
Compound: 1
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay
[PMID: 19432431]
Molecular Weight

551.59

Formula

C25H31F6N3O2S
CAS No.
SMILES

FC(F)(F)CN(C[C@]1(N2)[C@H]3CC4=C(C=CC(/C=C/CN5CCC(C(F)(F)F)CC5)=C4)C[C@@H]1CC3)S2(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRK 003 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRK 003623165-93-5MRK003MRK-003γ-secretaseApoptosisGamma secretasepancreatic ductal adenocarcinomahuman neuroblastoma cellInhibitorinhibitorinhibit

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