2. Apoptosis TGF-beta/Smad Epigenetics NF-κB Metabolic Enzyme/Protease Others
  3. Apoptosis PKC Keap1-Nrf2 Heme Oxygenase (HO) Drug Derivative
  4. MGF24

MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) (HY-113028)-induced apoptosis by inducing Heme oxygenase-1 (HO-1). MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MGF24

MGF24 Chemical Structure

CAS No. : 1611488-66-4

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MGF24 Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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HO-1 HO-2

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Description

MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) (HY-113028)-induced apoptosis by inducing Heme oxygenase-1 (HO-1). MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research[1].

Molecular Weight

2848.09

Formula

C121H195N41O39
CAS No.
Sequence

Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
Sequence Shortening

YQPPSTNKNTKSQRRKGSTFEEHK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MGF24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MGF241611488-66-4MGF 24MGF-24ApoptosisPKCKeap1-Nrf2Heme Oxygenase (HO)Drug DerivativeProtein kinase CHeme OxygenaseDrug derivativeMGFHO-1PKC-εNrf2SH-SY5Y cellsSheep models of myocardial ischemiaStrokeNerve injuryAmyotrophic lateral sclerosisInhibitorinhibitorinhibit

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