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ME-3277 is a potent GPIIb/IIIa antagonist. ME-3277 reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit middle cerebral artery (MCA). ME-3277 can be used for the acute cerebral infarction research.

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ME-3277

ME-3277 Chemical Structure

CAS No. : 165948-72-1

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ME-3277 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

ME-3277 is a potent GPIIb/IIIa antagonist. ME-3277 reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit middle cerebral artery (MCA). ME-3277 can be used for the acute cerebral infarction research[1].

IC50 & Target[1]

GPIIb/IIIa

 

In Vivo

ME-3277 (0.15, 0.3, and 0.6 mg/kg bolus, followed by 0.125, 0.25, and 0.5 mg/kg/h infusion, i.v., 30 min post-photochemical reaction for 24 h) reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit MCA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rabbits (2-3 kg) induced by photochemical reaction[1]
Dosage: 0.15, 0.3, and 0.6 mg/kg bolus, followed by 0.125, 0.25, and 0.5 mg/kg/h infusion
Administration: i.v., 30 min post-photochemical reaction for 24 h
Result: Inhibited ex vivo platelet aggregation significantly and maintained through the 24-hour period, with inhibition ratios of approximately 60, 80, and 90% at low, middle, and high doses, respectively.
Prolonged bleeding time at 2 or 24 hours after the photochemical reaction but by less than 2-fold at low dose.
Significantly prolonged the bleeding time by about 3-fold at both 2 hours and 24 hours at high dose.
Increased the total reflow time in a dose-dependent manner.
Significantly increased the total reflow time (31.7% vs. 3.8% in vehicle) and had a tendency to improve the 24 hours patency at high dose.
Significantly decreased the neurologic score to 3.5 at a low dose, 4.5 at a middle dose, and 3.5 at a high dose, respectively.
Decreased the infarct volume of total and cerebral cortex area to 13.1% and 4.7% at a low dose, 16.4% and 7.1% at a middle dose, and 12.9% and 5.2% at a high dose, respectively.
Significantly decreased the hemorrhagic volume.
The hemorrhage volume normalized to infarct volume did not differ significantly among the treatment groups and the vehicle control group.
Molecular Weight

448.45

Formula

C20H20N2O8S
CAS No.
SMILES

O=C(C1=CC=C(OCC(O)=O)C(OCC(O)=O)=C1)CNC(C(S2)=CC3=C2CCNC3)=O
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Purity & Documentation
References
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ME-3277 Related Classifications

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Help & FAQs
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ME-3277165948-72-1ME3277ME 3277IntegrinGPIIb/IIIacerebral infarctionmiddle cerebral arteryacute cerebral infarctionInhibitorinhibitorinhibit

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