2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. MDAN-21

MDAN-21 is a bivalent opioid ligand that contains both μ-opioid receptor agonists and δ-opioid receptor antagonists. MDAN-21 has a strong analgesic effect and does not produce tolerance in mouse studies. MDAN-21 can effectively inhibit the withdrawal of morphine dependent monkeys and alleviate abnormal pain in the study of rhesus monkeys. MDAN-21 can be used for the study of allodynia.

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MDAN-21

MDAN-21 Chemical Structure

CAS No. : 873573-64-9

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MDAN-21 Related Antibodies

Top Publications Citing Use of Products

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

MDAN-21 is a bivalent opioid ligand that contains both μ-opioid receptor agonists and δ-opioid receptor antagonists. MDAN-21 has a strong analgesic effect and does not produce tolerance in mouse studies. MDAN-21 can effectively inhibit the withdrawal of morphine dependent monkeys and alleviate abnormal pain in the study of rhesus monkeys. MDAN-21 can be used for the study of allodynia[1].

IC50 & Target[1]

μ Opioid Receptor/MOR

 

δ Opioid Receptor/DOR

 

Molecular Weight

1058.22

Formula

C58H71N7O12
CAS No.
SMILES

O[C@]12[C@]34[C@](OC5=C(O)C=CC(C[C@@]2([H])N(CC4)CC6CC6)=C53)([H])C7=C(C8=CC=CC(NC(COCC(NCCCCCCCNC(COCC(N[C@@H]9[C@@]%10([H])[C@]%11%12C%13=C(C[C@](N(CC%12)C)([H])[C@@]%11(CC9)O)C=CC(O)=C%13O%10)=O)=O)=O)=O)=C8N7)C1
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MDAN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDAN-21873573-64-9MDAN21MDAN 21Opioid Receptoropioid ligandanalgesicallodyniaInhibitorinhibitorinhibit

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