2. Academic Validation
  3. The novel cyclopropapyrroloindole(CPI) bisalkylators bearing 3,3'-(1,4-phenylene)diacryloyl group as a linker

The novel cyclopropapyrroloindole(CPI) bisalkylators bearing 3,3'-(1,4-phenylene)diacryloyl group as a linker

  • Bioorg Med Chem Lett. 1998 Aug 4;8(15):2003-4. doi: 10.1016/s0960-894x(98)00346-1.
Y Fukuda 1,  S Seto,  H Furuta,  H Ebisu,  Y Oomori,  S Terashima
Affiliations

Affiliation

  • 1 Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd., Tochigi, Japan.
PMID: 9873475 DOI: 10.1016/s0960-894x(98)00346-1
Abstract

The novel cyclopropapyrroloindole(CPI) bisalkylators were synthesized and their antitumor activity was evaluated. Among these derivatives, AT-760 (5a) in which the two 3-methoxycarbonyl-2-trifluoromethylCPI (MCTFCPI) moieties are connected with a 3,3'-(1,4-phenylene)diacryloyl group, was found to exhibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin) (1).

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