2. Academic Validation
  3. A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair

A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair

  • Bioorg Med Chem Lett. 1998 Mar 3;8(5):453-8. doi: 10.1016/s0960-894x(98)00051-1.
D Guay 1,  J Y Gauthier,  C Dufresne,  T R Jones,  M McAuliffe,  C McFarlane,  K M Metters,  P Prasit,  C Rochette,  P Roy,  N Sawyer,  R Zamboni
Affiliations

Affiliation

  • 1 Merck Frosst Center for Therapeutic Research, Québec, Canada.
PMID: 9871597 DOI: 10.1016/s0960-894x(98)00051-1
Abstract

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L-733,321) as an optimized candidate.

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