2. Academic Validation
  3. Stereospecificity of 2,4-diaminobutyric acid with respect to inhibition of 4-aminobutyric acid uptake and binding

Stereospecificity of 2,4-diaminobutyric acid with respect to inhibition of 4-aminobutyric acid uptake and binding

  • Br J Pharmacol. 1977 Jan;59(1):218-9. doi: 10.1111/j.1476-5381.1977.tb06998.x.
G A Johnston,  B Twitchin
PMID: 837002 DOI: 10.1111/j.1476-5381.1977.tb06998.x
Abstract

S(+)-2,4-Diaminobutyric acid is at least 20 times more potent than the R(-) stereoisomer as an inhibitor of the sodium-dependent uptake of 4-aminobutyric acid (GABA) in rat brain slices. Both isomers, however, are equipotent as inhibitors of sodium-independent binding of GABA to membranes from rat brain. The latter finding may be relevant to the reported neurotoxicity in rats of both isomers of 2,4-diaminobutyric acid after intracisternal injection.

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