2. Academic Validation
  3. Microbial hydroxylation of novobiocin and related compounds

Microbial hydroxylation of novobiocin and related compounds

  • J Antibiot (Tokyo). 1984 Feb;37(2):136-42. doi: 10.7164/antibiotics.37.136.
O K Sebek,  L A Dolak
PMID: 6706850 DOI: 10.7164/antibiotics.37.136
Abstract

A new soil actinomycete (UC 5762, NRRL 11111) was found to transform novobiocin to 11-hydroxynovobiocin. The product was isolated by solvent extraction and column chromatography, and identified by IR, UV, 1H NMR and 13C NMR spectroscopy. Related structures (8,9-dihydronovobiocin, novobiocic acid and chlorobiocin) were similarly transformed to their corresponding C-11 hydroxylated analogues. The microbial process is superior to chemical (selenium dioxide) oxidation which yielded a mixture of 11-hydroxy- and 11-oxonovobiocin.

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