2. Academic Validation
  3. A sensitive and specific stable isotope assay for warfarin and its metabolites

A sensitive and specific stable isotope assay for warfarin and its metabolites

  • Biomed Mass Spectrom. 1983 Jul;10(7):395-8. doi: 10.1002/bms.1200100702.
E D Bush,  L K Low,  W F Trager
PMID: 6616017 DOI: 10.1002/bms.1200100702
Abstract

A capillary gas chromatographic mass spectrometric method for the quantification of warfarin and its known metabolites from microsomal incubations is described. Deuterium labelled 4', 6-, 7- and 8-hydroxy warfarins are used as internal standards and the method has detection limits of 1 ng ml-1 with 20 ng ml-1 being the lower limit for accurate quantification.

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