2. Academic Validation
  3. Initial experiments with cyproterone acetate and 1-amino-3-chloro-2-propanol hydrochloride in the male Virginia opossum (Didelphis virginiana)

Initial experiments with cyproterone acetate and 1-amino-3-chloro-2-propanol hydrochloride in the male Virginia opossum (Didelphis virginiana)

  • Andrologia. 1983 Jan-Feb;15(1):50-6. doi: 10.1111/j.1439-0272.1983.tb00114.x.
E Heath,  S Olusanya,  G Pijanowski
PMID: 6220622 DOI: 10.1111/j.1439-0272.1983.tb00114.x
Abstract

Cyproterone acetate (CA) was toxic for Didelphis virginiana at a dose range of 22-28 mg/kg IM. A loss of spermatozoal pairing int the cauda epididymidis did not occur until 2 wk after testicular degeneration caused by CA. The isomers of 1-amino-3-chloro-2-propanol hydrochloride (CL 88,236 and CL 88,237) were well tolerated by the opossum at doses up to 30 mg/kg IM. After 8 days of CL 88,236 and CL 88,237 treatment there was no effect on spermatozoal pairing in the cauda epididymidis or on the seminiferous epithelium.

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