2. Academic Validation
  3. TRPV2 Regulates Function of Human Neutrophil Granulocytes

TRPV2 Regulates Function of Human Neutrophil Granulocytes

  • FASEB J. 2025 Sep 30;39(18):e71052. doi: 10.1096/fj.202501585RR.
Anna S Heinemann 1,  Tabea C Fricke 1,  Christine Herzog 1,  Frank G Echtermeyer 1,  Andreas Leffler 1
Affiliations

Affiliation

  • 1 Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
PMID: 40948391 DOI: 10.1096/fj.202501585RR
Abstract

Neutrophils play a vital role in human immune defense, and their dysregulation can cause collateral damage in sepsis and autoimmune diseases. We provide evidence for the involvement of the transient receptor potential vanilloid 2 (TRPV2) in cytokine expression and transmigration in human neutrophils as well as in HL60 cells. These data identify TRPV2 as a candidate target for novel therapeutics regulating neutrophil activity.

Keywords

TRPV2; cytokine; innate immunity; migration; neutrophils.

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