2. Academic Validation
  3. Role of circ_0012856 in modulating molecular pathways of diabetic peripheral neuropathy

Role of circ_0012856 in modulating molecular pathways of diabetic peripheral neuropathy

  • J Cell Commun Signal. 2025 Jun 12;19(2):e70019. doi: 10.1002/ccs3.70019.
Ji Chen 1,  Fan Zhang 2,  Yangyuxi Chen 3,  Yingqing Lu 2,  Xinxin Liu 4,  Yuanzhang Tang 5,  Fengrui Yang 4
Affiliations

Affiliations

  • 1 Department of Endocrinology Hunan University of Medicine General Hospital Huaihua Hunan China.
  • 2 Department of Anesthesiology Xiangya Hospital of Central South University Changsha Hunan Province China.
  • 3 Yali High School International Department Changsha Hunan China.
  • 4 Department of Anesthesiology Hunan University of Medicine General Hospital (Jishou University of Huaihua Hospital) Huaihua Hunan China.
  • 5 Department of Pain Management The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China.
PMID: 40520073 DOI: 10.1002/ccs3.70019
Abstract

Diabetic peripheral neuropathy (DPN), a common complication of diabetes mellitus, involves complex molecular pathways and the ceRNA regulatory network. Integration of diabetes-related circRNA datasets identified circ_0012856 as pivotal via least absolute shrinkage and selection operator and support vector machine recursive feature elimination algorithms. Functional enrichment analyses elucidated its involvement in DPN pathogenesis. In vitro studies showed circ_0012856 regulating EZH2 and STAT3 expressions, inhibiting Autophagy, and promoting microglial M1 polarization. In vivo, experiments revealed silencing circ_0012856 alleviating DPN symptoms in diabetic mice. Overall, circ_0012856 acts as a miR-124 Sponge, affecting key pathways in DPN progression and providing potential therapeutic targets.

Keywords

EZH2; MicroRNA‐124; STAT3; autophagy; circ_0012856; diabetic peripheral neuropathy; microglial polarization.

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