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  2. Salidroside alleviates atopic dermatitis-like responses by inhibiting MAPKs and NF-κB signaling pathways

Salidroside alleviates atopic dermatitis-like responses by inhibiting MAPKs and NF-κB signaling pathways

  • Arch Dermatol Res. 2025 Apr 1;317(1):666. doi: 10.1007/s00403-025-04091-4.
Miaomiao Wang 1 2 Yujie Xiong 3
Affiliations

Affiliations

  • 1 Department of Traditional Chinese Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China. wmmiao876@hotmail.com.
  • 2 First Affiliated Hospital of Bengbu Medical University, No.287, Changhuai Road, Longzihu, Bengbu City, Anhui Province, China. wmmiao876@hotmail.com.
  • 3 Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, 210029, China.
Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Salidroside, a major component of Acer tegmentosum, may be a valuable candidate for developing anti-AD agents. In this study, we investigated the therapeutic roles of salidroside and its related mechanisms in AD. For in vivo experiments, male BALB/c mice were challenged with 2,4-dinitrochlorobenzene (DNCB) to induce AD-like lesions and orally administered with salidroside for AD-like manifestations were induced by DNCB. Histological changes were assessed via hematoxylin-eosin staining and toluidine blue staining. Scratching numbers and spleen weight were evaluated. For in vitro experiments, TNF-α/IFN-γ-treated HaCaT cells and primary keratinocytes were used. Pro-inflammatory factors and pathway-associated proteins levels were measured by RT-qPCR and western blotting. Salidroside reduced the release of pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-treated HaCaT cells and primary keratinocytes. Salidroside alleviated DNCB-induced AD-like symptoms in mice. Salidroside attenuated the DNCB-induced atopic skin inflammation in vivo. Mechanistically, salidroside inactivated MAPK and NF-κB pathways in vitro and in vivo. Salidroside ameliorates AD-like responses via inactivating the MAPK and NF-κB pathways.

Keywords

Atopic dermatitis; Inflammation; MAPKs; NF-κB; Salidroside.

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