2. Academic Validation
  3. A Novel Polysaccharide from the Flowers of Lilium lancifolium Alleviates Pulmonary Fibrosis In Vivo and In Vitro

A Novel Polysaccharide from the Flowers of Lilium lancifolium Alleviates Pulmonary Fibrosis In Vivo and In Vitro

  • J Agric Food Chem. 2025 Apr 2;73(13):7774-7787. doi: 10.1021/acs.jafc.4c11703.
Renjie Liu 1 2,  Tong Wu 1 2,  Wanqi Zhou 1 3,  Anming Zhu 1,  Wenfeng Liao 1 2,  Kan Ding 1 2 4
Affiliations

Affiliations

  • 1 Carbohydrate Drug Research Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
  • 2 University of Chinese Academy of Sciences, No.19Auquan Road, Beijing 100049, China.
  • 3 School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • 4 ZhongShan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Zhongshan 528400, China.
PMID: 40114341 DOI: 10.1021/acs.jafc.4c11703
Abstract

Lily flowers are widely used in China for lung nourishment; however, their active ingredients remain unknown. To address this question, we isolated a novel polysaccharide (L005-B) from the flowers of Lilium lancifolium. Its backbone is comprised of Glcp, Galp, and 1,2-linked α-Rhap. The branch is composed of Xyl and T-α-Glcp residues substituted at the C-4 position of Rhap, along with portions of Glcp, Galp, Araf, and GlcpA residues substituted at the C-4 position of glucose or the C-3 position of galactose. Bioactivity study showed that L005-B alleviated fibrosis-associated protein (fibronectin, Collagen, α-SMA) expression in TGF-β1-induced human fibroblast cells (MRC-5). Moreover, L005-B significantly inhibited the epithelial-mesenchymal transition of the human alveolar type II epithelial cell. More importantly, L005-B dramatically improved bleomycin-induced histopathological changes and attenuated the pulmonary index and hydroxyproline contents. Taken together, our findings revealed that L005-B may serve as a promising leading compound for the development of novel antipulmonary fibrosis therapeutics.

Keywords

Lilium lancifolium; epithelial–mesenchymal transition; homogeneous polysaccharide; pulmonary fibrosis.

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