2. Academic Validation
  3. Liposomal curcumin inhibits cigarette smoke induced senescence and inflammation in human bronchial epithelial cells

Liposomal curcumin inhibits cigarette smoke induced senescence and inflammation in human bronchial epithelial cells

  • Pathol Res Pract. 2024 Aug:260:155423. doi: 10.1016/j.prp.2024.155423.
Sofia Kokkinis 1,  Gabriele De Rubis 2,  Keshav Raj Paudel 3,  Vyoma K Patel 4,  Stewart Yeung 2,  Victoria Jessamine 2,  Ronan MacLoughlin 5,  Philip M Hansbro 6,  Brian Oliver 7,  Kamal Dua 8
Affiliations

Affiliations

  • 1 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia; Pharmako Biotechnologies, Frenchs Forest, NSW 2086, Australia.
  • 2 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
  • 3 Centre for Inflammation, Faculty of Science, School of Life Sciences, Centenary Institute and University of Technology Sydney, Sydney, NSW 2007, Australia. Electronic address: keshavraj.paudel@uts.edu.au.
  • 4 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia; Faculty of Health and Medicine, School of Clinical Medicine, University of New South Wales, NSW 2031, Australia.
  • 5 Research and Development, Science and Emerging Technologies, Aerogen Ltd., Galway Business Park, Galway H91 HE94, Ireland; School of Pharmacy and Biomolecular Science, Royal College of Surgeons in Ireland, Dublin D02YN77, Ireland; School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin D02PN40, Ireland.
  • 6 Centre for Inflammation, Faculty of Science, School of Life Sciences, Centenary Institute and University of Technology Sydney, Sydney, NSW 2007, Australia.
  • 7 School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia; Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia.
  • 8 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address: Kamal.dua@uts.edu.au.
PMID: 38909404 DOI: 10.1016/j.prp.2024.155423
Abstract

Curcumin, the principal curcuminoid of turmeric (Curcuma longa extract), is very well known for its multiple biological therapeutic activities, particularly its anti-inflammatory and antioxidant potential. However, due to its low water solubility, it exhibits poor bioavailability. In order to overcome this problem, in the current study, we have employed liposomal technology to encapsulate curcumin with the aim of enhancing its therapeutic efficacy. The curcumin-loaded liposomes (PlexoZome®) were tested on a cigarette smoke extract-induced Chronic Obstructive Pulmonary Disease (COPD) in vitro model using minimally immortalized human bronchial epithelial cells (BCiNS1.1). The anti-senescence and anti-inflammatory properties of PlexoZome® were explored. 5 µM PlexoZome® curcumin demonstrated anti-senescent activity by decrease in X-gal positive cells, and reduction in the expression of p16 and p21 in immunofluorescence staining. Moreover, PlexoZome® curcumin also demonstrated a reduction in proteins related to senescence (Osteopontin, FGF basic and uPAR) and inflammation (GM-CSF, EGF and ST2). Overall, the results clearly demonstrate the therapeutic potential of curcumin encapsulated liposomes in managing CSE induced COPD, providing a new direction to respiratory clinics.

Keywords

Chronic Obstructive Pulmonary Disease; Curcumin; Liposomes; Nanoparticles; Phytoceuticals; PlexoZome®.

Figures
Products