2. Academic Validation
  3. Influence of N,N'-(1,11-undecandiyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide) (BAY 02752) on gallstone formation and regression in hamsters

Influence of N,N'-(1,11-undecandiyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide) (BAY 02752) on gallstone formation and regression in hamsters

  • Pharmacol Res Commun. 1987 Oct;19(10):679-84. doi: 10.1016/0031-6989(87)90098-1.
D Kritchevsky 1,  D M Klurfeld
Affiliations

Affiliation

  • 1 Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
PMID: 3441483 DOI: 10.1016/0031-6989(87)90098-1
Abstract

A new hypolipidemic drug (BAY 02752) when added to a lithogenic hamster diet at dosages of 1000 and 500 mg per kg of diet significantly (p less than 0.005) inhibited gallstone formation. When BAY 02752 was fed to hamsters with pre-established gallstones, it inhibited progression (p=0.052) of the stones and appeared to promote dissolution.

Figures
Products