2. Academic Validation
  3. Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma

Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma

  • Mar Drugs. 2020 Sep 18;18(9):474. doi: 10.3390/md18090474.
Shohei Tsuji 1,  Shinsuke Nakamura 1,  Takashi Maoka 2,  Tetsuya Yamada 1 3,  Takahiko Imai 1,  Takuya Ohba 1,  Tomohiro Yako 1,  Masahiro Hayashi 4,  Ken Endo 5,  Masanao Saio 6,  Hideaki Hara 1,  Masamitsu Shimazawa 1
Affiliations

Affiliations

  • 1 Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu 501-1196, Japan.
  • 2 Research Institute for Production Developent Division of Food Function and Chemistry, Kyoto 606-0805, Japan.
  • 3 Department of Neurosurgery, Gifu University School of Medicine, Gifu 501-1194, Japan.
  • 4 Department of HPM Research & Development, Biotechnology R&D Group, High Performance Materials Company, ENEOS Corporation, Yokohama 231-0815, Japan.
  • 5 Department of HPM Business Promotion Group V, Business promotion Group, High Performance Materials Company, ENEOS Corporation, Tokyo 108-8005, Japan.
  • 6 Graduate School of Health Sciences, Gunma University, Gunma 371-8514, Japan.
PMID: 32962073 DOI: 10.3390/md18090474
Abstract

Several antitumour drugs have been isolated from natural products and many clinical trials are underway to evaluate their potential. There have been numerous reports about the antitumour effects of astaxanthin against several tumours but no studies into its effects against glioblastoma. Astaxanthin is a red pigment found in crustaceans and fish and is also synthesized in Haematococcus pluvialis; adonixanthin is an intermediate product of astaxanthin. It is known that both astaxanthin and adonixanthin possess radical scavenging activity and can confer a protective effect on several damages. In this study, we clarified the antitumour effects of astaxanthin and adonixanthin using glioblastoma models. Specifically, astaxanthin and adonixanthin showed an ability to suppress cell proliferation and migration in three types of glioblastoma cells. Furthermore, these compounds were confirmed to transfer to the brain in a murine model. In the murine orthotopic glioblastoma model, glioblastoma progression was suppressed by the oral administration of astaxanthin and adonixanthin at 10 and 30 mg/kg, respectively, for 10 days. These results suggest that both astaxanthin and adonixanthin have potential as treatments for glioblastoma.

Keywords

brain; cancer; oral administration; paracoccsu carotinifaciens; xanthophyll carotenoid.

Figures
Products