2. Academic Validation
  3. Coumarin and Moracin Derivatives from Mulberry Leaves (Morus alba L.) with Soluble Epoxide Hydrolase Inhibitory Activity

Coumarin and Moracin Derivatives from Mulberry Leaves (Morus alba L.) with Soluble Epoxide Hydrolase Inhibitory Activity

  • Molecules. 2020 Aug 31;25(17):3967. doi: 10.3390/molecules25173967.
Hong Xu Li 1 2,  Myungsook Heo 3,  Younghoon Go 4,  Young Soo Kim 4,  Young Ho Kim 3,  Seo Young Yang 3,  Wei Li 4
Affiliations

Affiliations

  • 1 Shenzhen Key Laboratory of Marine Bioresource and Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
  • 2 College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
  • 3 College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
  • 4 Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea.
PMID: 32878149 DOI: 10.3390/molecules25173967
Abstract

This study identified three Coumarins (1-3), and six moracin derivatives (4-9). The structures of these natural compounds were determined by the spectroscopic methods, including 1D and 2D NMR methods, and comparison with previous reported data. All of the isolated compounds were assessed for the effects on the soluble Epoxide Hydrolase (sEH) inhibitory activity. Among them, compounds 1-7 exhibited significant inhibitory effect with 100% inhibitory, with IC50 values of 6.9, 0.2, 15.9, 1.1, 1.2, 9.9, and 7.7 µM, respectively. A kinetic study revealed that compounds 1-4, and 6 were competitive types of inhibitors, compounds 5 and 7 were mixed types of inhibitors. These results suggest that moracin and coumarin derivatives from mulberry leaves are significant sEH inhibitors.

Keywords

Morus alba; coumarin; moracin; soluble epoxide hydrolase (sEH).

Figures
Products