2. Academic Validation
  3. A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

  • Nat Commun. 2020 Mar 24;11(1):1539. doi: 10.1038/s41467-020-15344-3.
Corina N D'Alessandro-Gabazza # 1 2 3,  Tetsu Kobayashi # 4,  Taro Yasuma # 1 2 5,  Masaaki Toda # 1 2,  Heejin Kim # 3,  Hajime Fujimoto 4,  Osamu Hataji 6,  Atsuro Takeshita 1 5,  Kota Nishihama 5,  Tomohito Okano 4,  Yuko Okano 1 5,  Yoichi Nishii 6,  Atsushi Tomaru 4,  Kentaro Fujiwara 4 6,  Valeria Fridman D'Alessandro 1,  Ahmed M Abdel-Hamid 3,  Yudong Ren 3 7,  Gabriel V Pereira 3 8,  Christy L Wright 9,  Alvaro Hernandez 9,  Christopher J Fields 9,  Peter M Yau 9,  Shujie Wang 10,  Akira Mizoguchi 10,  Masayuki Fukumura 11 12,  Junpei Ohtsuka 11 12,  Tetsuya Nosaka 12,  Kensuke Kataoka 13,  Yasuhiro Kondoh 13,  Jing Wu 14,  Hirokazu Kawagishi 14 15,  Yutaka Yano 5,  Roderick I Mackie 3 8 16,  Isaac Cann 17 18 19 20 21,  Esteban C Gabazza 22 23 24
Affiliations

Affiliations

  • 1 Department of Immunology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
  • 2 Center for Intractable Diseases, Mie University, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
  • 3 Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • 4 Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
  • 5 Department of Diabetes and Endocrinology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
  • 6 Respiratory Center, Matsusaka Municipal Hospital, Tonomachi 1550, Matsusaka, Mie, 515-8544, Japan.
  • 7 The School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • 8 Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • 9 W.M. Keck Center for Functional and Comparative Genomics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • 10 Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu, Mie, 14101, Japan.
  • 11 BioComo Incorporation, Komono, Mie, 510-1233, Japan.
  • 12 Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu, Mie, 514-8507, Japan.
  • 13 Department of Respiratory Medicine and Allergy, Tosei General Hospital, 160 Nishioiwake-cho, Seto, Aichi, 489-8642, Japan.
  • 14 Research Institute of Green Science and Technology, Graduate School of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
  • 15 Green Chemistry Research Division, Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
  • 16 Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • 17 Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana-Champaign, Urbana, IL, USA. icann@illinois.edu.
  • 18 The School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. icann@illinois.edu.
  • 19 Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA. icann@illinois.edu.
  • 20 Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA. icann@illinois.edu.
  • 21 Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. icann@illinois.edu.
  • 22 Department of Immunology, Mie University Faculty and Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan. gabazza@doc.medic.mie-u.ac.jp.
  • 23 Center for Intractable Diseases, Mie University, Edobashi 2-174, Tsu, Mie, 514-8507, Japan. gabazza@doc.medic.mie-u.ac.jp.
  • 24 Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana-Champaign, Urbana, IL, USA. gabazza@doc.medic.mie-u.ac.jp.
  • # Contributed equally.
PMID: 32210242 DOI: 10.1038/s41467-020-15344-3
Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology; however, Apoptosis of lung alveolar epithelial cells plays a role in disease progression. This intractable disease is associated with increased abundance of Staphylococcus and Streptococcus in the lungs, yet their roles in disease pathogenesis remain elusive. Here, we report that Staphylococcus nepalensis releases corisin, a peptide conserved in diverse staphylococci, to induce Apoptosis of lung epithelial cells. The disease in mice exhibits acute exacerbation after intrapulmonary instillation of corisin or after lung Infection with corisin-harboring S. nepalensis compared to untreated mice or mice infected with bacteria lacking corisin. Correspondingly, the lung corisin levels are significantly increased in human IPF patients with acute exacerbation compared to patients without disease exacerbation. Our results suggest that bacteria shedding corisin are involved in acute exacerbation of IPF, yielding insights to the molecular basis for the elevation of staphylococci in pulmonary fibrosis.

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