Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon

J Nat Prod. 2019 Oct 25;82(10):2828-2834. doi: 10.1021/acs.jnatprod.9b00522.

Yuen P Tan, Yongbo Xue ¹, Andrei I Savchenko, Sevan D Houston, Naphak Modhiran, Christopher L D McMillan, Glen M Boyle ², Paul V Bernhardt, Paul R Young, Daniel Watterson, Craig M Williams

Affiliations

1 School of Pharmaceutical Sciences (Shenzhen) , Sun Yat-Sen University , Guangzhou , 510275 , People's Republic of China.
2 QIMR Berghofer Medical Research Institute , PO Royal Brisbane Hospital, Brisbane , 4029 , Queensland , Australia.

PMID: 31553187 DOI: 10.1021/acs.jnatprod.9b00522

Abstract

The highly oxygenated pimarane Diterpenoids basimarols A, B, and C (3-5) were isolated from the plant species Basilicum polystachyon, which was collected within the Australian arid zone. Structure elucidation was performed using a suite of spectroscopic techniques, including X-ray crystallography. Anticancer and anti-DENV activity of 3-5 was explored, but only limited activity was observed. More extensive Antiviral evaluation of stachyonic acid A (1), which was also isolated from B. polystachyon, revealed broad spectrum Antiviral activity against West Nile virus (Kunjin strain, WNV_Kun) and human influenza viruses H1N1 and H3N2.

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