2. Academic Validation
  3. Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata

Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata

  • Acta Pharm Sin B. 2016 Nov;6(6):564-567. doi: 10.1016/j.apsb.2016.05.009.
Chuangfeng Zhang 1,  Jian Zhou 2,  Jingzhi Yang 1,  Chuangjun Li 1,  Jie Ma 1,  Dan Zhang 1,  Dongming Zhang 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
PMID: 27818923 DOI: 10.1016/j.apsb.2016.05.009
Abstract

Two new phenylpropanoid glycosides named cuneataside E (1) and cuneataside F (2), were isolated from the aerial parts of Lespedeza cuneata (Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 μmol/L, compound 1 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HeG2 cells.

Keywords

Cuneataside E; Cuneataside F; Extraction and isolation; Hepatoprotective activity; Lespedeza cuneata; Phenylpropanoid glycosides.

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